Association between cigarette smoking, APCmutations and the risk of developing sporadic colorectal adenomas and carcinomas

Table 4 Adenomas, smoking history and APC truncation mutation status.

Smoking parameters^a	All adenomas^b versus controls	APC⁺ versus controls	APC^- versus controls	APC⁺versus APC^-
Never smoked§
Case/control	13/157	*6/157	*4/157	6/4
Ever smoked
Case/control	34/177	*11/177	*22/177	11/22
OR (95% CI)	1.73 (0.83–3.58)	0.96 (0.33–2.85)	3.97 (1.26–12.51)	0.24 (0.05–1.11)

*Missing values for "ever smoked" gave rise to diminished numbers of adeoma cases.
§ Never smoked serves as the reference category.
^aAll the OR's are adjusted for age and sex.
^bFor overall case-control comparison of adenoma status and smoking all the selected adenoma cases from the study population that had completed the questionnaire for smoking parameters were used 47/48.

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