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Table 2 APC mutational spectra detected in all adenoma/CRC cases, and cases divided according to smoking status.

From: Association between cigarette smoking, APCmutations and the risk of developing sporadic colorectal adenomas and carcinomas

Type of mutationa

All cases n = 133 Total number of mutations

Ever smokers*b n = 88

Never smokers*b n = 39

  

Silent/missense mutation

Truncation mutation

Silent/missense mutation

Truncation mutation

Transitions

31(39%)

13 (72%)

7 (25%)

7 (50%)

2 (13%)

C → T

17

2

7

4

2

G → A

9

6

-

3

-

A → G

4

4

-

-

-

T → C

1

1

-

-

-

Transversion

21(26%)

5 (28%)

5 (18%)

7 (50%)

2 (13%)

A → C

-

-

-

-

-

T → G

2

1

-

1

-

A → T

1

-

1

-

-

T → A

4

2

-

2

-

C → A

3

1

2

-

-

G → T

6

1

2

1

2

C → G

-

-

-

 

-

G → C

3

-

-

3

-

Frameshift

28 (35%)

-

16 (57%)

-

11 (74%)

Total

80

18

28

14

15

  1. *Missing values for ever and never smoking gave rise to diminished numbers of cases and mutations.
  2. a The frequency is calculated by dividing the number of transitions, transversions and framshift mutations separately to the total number of either silent/missens or truncated mutations for ever and never smokers.
  3. bThere is no significant difference between ever smokers and never smokers in relation to the mutational spectra (transitions, transversions and frameshift) for missens/silent or truncated mutations P = 0.094 and 0.558, respectively.