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Table 5 Combinations of XRCC1 Arg280His and XRCC1 Arg399Gln polymorphisms and risk of colorectal carcinomas and adenomas. ORs are adjusted for age.

From: Polymorphisms of the XRCC1, XRCC3 and XPDgenes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study

Case group

 

OR (95 % CI) (N case/N controls)

 

XRCC1Arg399Gln

XRCC1Arg280His

 

Carcinomas

 

GG

GA

 

GG

1.0a (56/137)

1.93 (0.44–8.49) (7/11)

 

GA

0.76 (0.41–1.38) (65/180)

1.18 (0.20–7.02) (5/7)

 

AA

0.96 (0.44–2.09) (24/64)

-

Adenomas

 

GG

GA

 

GG

1.0a (341/137)

1.75 (0.85–3.63) (50/11)

 

GA

0.85 (0.64–1.13) (415/180)

1.22 (0.50–3.00) (27/7)

 

AA

0.93 (0.44–1.36) (149/64)

-

High-risk adenomas

 

GG

GA

 

GG

1.0a (83/137)

2.92 (1.20–7.10) (17/11)

 

GA

0.77 (0.51–1.15) (92/180)

0.63 (0.14–2.71) (3/7)

 

AA

0.74 (0.42–1.29) (32/64)

-

Low-risk adenomas

 

GG

GA

 

GG

1.0a (258/137)

1.43 (0.66–3.09) (33/11)

 

GA

0.88 (0.65–1.18) (324/180)

1.47 (0.59–3.66) (24/7)

 

AA

1.00 (0.67–1.48) (117/64)

 
  1. a The genotype served as a reference category