Skip to main content

Table 5 Combinations of XRCC1 Arg280His and XRCC1 Arg399Gln polymorphisms and risk of colorectal carcinomas and adenomas. ORs are adjusted for age.

From: Polymorphisms of the XRCC1, XRCC3 and XPDgenes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study

Case group   OR (95 % CI) (N case/N controls)
  XRCC1Arg399Gln XRCC1Arg280His  
Carcinomas   GG GA
  GG 1.0a (56/137) 1.93 (0.44–8.49) (7/11)
  GA 0.76 (0.41–1.38) (65/180) 1.18 (0.20–7.02) (5/7)
  AA 0.96 (0.44–2.09) (24/64) -
Adenomas   GG GA
  GG 1.0a (341/137) 1.75 (0.85–3.63) (50/11)
  GA 0.85 (0.64–1.13) (415/180) 1.22 (0.50–3.00) (27/7)
  AA 0.93 (0.44–1.36) (149/64) -
High-risk adenomas   GG GA
  GG 1.0a (83/137) 2.92 (1.20–7.10) (17/11)
  GA 0.77 (0.51–1.15) (92/180) 0.63 (0.14–2.71) (3/7)
  AA 0.74 (0.42–1.29) (32/64) -
Low-risk adenomas   GG GA
  GG 1.0a (258/137) 1.43 (0.66–3.09) (33/11)
  GA 0.88 (0.65–1.18) (324/180) 1.47 (0.59–3.66) (24/7)
  AA 1.00 (0.67–1.48) (117/64)  
  1. a The genotype served as a reference category