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Table 4 Distributions of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln genotypes and development of colorectal carcinomas and adenomas. ORs are adjusted for age, gender, cigarette smoking and alcohol consumption.

From: Polymorphisms of the XRCC1, XRCC3 and XPDgenes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study

Genotypes

Controls

Carcinomas

OR (95% CI)

Adenomas

OR (95% CI)

High-risk adenomas

OR (95% CI)

Low-risk adenomas

OR (95% CI)

XRCC1Arg194Trp

Arg/Arg (CC)

292

92

1a

734

1a

166

1a

568

1a

Arg/Trp (CT)

39

11

0.82 (0.27–2.47)

89

0.95 (0.61–1.48)

22

1.37 (0.72–2.60)

67

0.85 (0.53–1.36)

Trp/Trp (TT)

1

2

-

4

-

1

-

3

-

Arg/Trp + Trp/Trp

40

13

0.84 (0.28–2.48)

93

0.96 (0.62–1.49)

23

1.35 (0.71–2.56)

70

0.87 (0.55–1.38)

Missing

 

1

       

XRCC1 Arg 280 His

Arg/Arg (GG)

319

100

1a

764

1a

174

1a

590

1a

Arg/His (GA)

13

6

1.48 (0.29–7.48)

63

2.30 (1.19–4.46)

15

3.82 (1.59–9.18)

48

2.07 (1.05–4.10)

His/His (AA)

0

0

-

0

-

0

-

0

-

XRCC1 Arg 399 Gln

Arg/Arg (GG)

119

39

1a

326

1a

82

1a

244

1a

Arg/Gln (GA)

159

51

0.87 (0.43–1.78)

371

0.74 (0.54–1.01)

79

0.59 (0.37–0.94)

292

0.79 (0.57–1.09)

Gln/Gln (AA)

54

16

1.05 (0.40–2.75)

130

0.93 (0.61–1.42)

28

0.73 (0.39–1.37)

102

0.97 (0.62–1.51)

Arg/Gln + Gln/Gln

213

67

0.91 (0.47–1.79)

500

0.78 (0.59–1.05)

107

0.62 (0.41–0.96)

394

0.83 (0.61–1.13)

XRCC3 Thr 241 Met

Thr/Thr (CC)

116

45

1a

324

1a

70

1a

254

1a

Thr/Met (CT)

169

48

1.18 (0.57–2.42)

380

0.83 (0.61–1.14)

91

1.06 (0.67–1.68)

289

0.78 (0.57–1.08)

Met/Met (TT)

47

13

1.29 (0.45–3.69)

123

1.03 (0.66–1.60)

28

1.25 (0.65–2.39)

95

1.01 (0.64–1.59)

Thr/Met + Met/Met

216

61

1.20 (0.60–2.39)

502

0.88 (0.65–1.18)

119

1.10 (0.71–1.71)

384

0.83 (0.61–1.13)

XPD Lys 751 Gln

Lys/Lys (AA)

148

43

1a

300

1a

69

1a

231

1a

Lys/Gln (AC)

142

47

0.81 (0.40–1.67)

390

1.35 (0.99–1.83)

86

1.27 (0.81–2.01)

304

1.33 (0.97–1.84)

Gln/Gln (CC)

41

15

1.00 (0.38–2.62)

136

1.66 (1.07–2.58)

34

1.59 (0.85–2.99)

102

1.61 (1.02–2.54)

Lys/Gln + Gln/Gln

183

62

0.86 (0.44–1.68)

526

1.42 (1.06–1.89)

120

1.35 (0.88–2.06)

406

1.40 (1.03–1.89)

Missing

1

1

     

1

 
  1. a The genotype served as reference category