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Table 4 Distributions of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln genotypes and development of colorectal carcinomas and adenomas. ORs are adjusted for age, gender, cigarette smoking and alcohol consumption.

From: Polymorphisms of the XRCC1, XRCC3 and XPDgenes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study

Genotypes Controls Carcinomas OR (95% CI) Adenomas OR (95% CI) High-risk adenomas OR (95% CI) Low-risk adenomas OR (95% CI)
XRCC1Arg194Trp
Arg/Arg (CC) 292 92 1a 734 1a 166 1a 568 1a
Arg/Trp (CT) 39 11 0.82 (0.27–2.47) 89 0.95 (0.61–1.48) 22 1.37 (0.72–2.60) 67 0.85 (0.53–1.36)
Trp/Trp (TT) 1 2 - 4 - 1 - 3 -
Arg/Trp + Trp/Trp 40 13 0.84 (0.28–2.48) 93 0.96 (0.62–1.49) 23 1.35 (0.71–2.56) 70 0.87 (0.55–1.38)
Missing   1        
XRCC1 Arg 280 His
Arg/Arg (GG) 319 100 1a 764 1a 174 1a 590 1a
Arg/His (GA) 13 6 1.48 (0.29–7.48) 63 2.30 (1.19–4.46) 15 3.82 (1.59–9.18) 48 2.07 (1.05–4.10)
His/His (AA) 0 0 - 0 - 0 - 0 -
XRCC1 Arg 399 Gln
Arg/Arg (GG) 119 39 1a 326 1a 82 1a 244 1a
Arg/Gln (GA) 159 51 0.87 (0.43–1.78) 371 0.74 (0.54–1.01) 79 0.59 (0.37–0.94) 292 0.79 (0.57–1.09)
Gln/Gln (AA) 54 16 1.05 (0.40–2.75) 130 0.93 (0.61–1.42) 28 0.73 (0.39–1.37) 102 0.97 (0.62–1.51)
Arg/Gln + Gln/Gln 213 67 0.91 (0.47–1.79) 500 0.78 (0.59–1.05) 107 0.62 (0.41–0.96) 394 0.83 (0.61–1.13)
XRCC3 Thr 241 Met
Thr/Thr (CC) 116 45 1a 324 1a 70 1a 254 1a
Thr/Met (CT) 169 48 1.18 (0.57–2.42) 380 0.83 (0.61–1.14) 91 1.06 (0.67–1.68) 289 0.78 (0.57–1.08)
Met/Met (TT) 47 13 1.29 (0.45–3.69) 123 1.03 (0.66–1.60) 28 1.25 (0.65–2.39) 95 1.01 (0.64–1.59)
Thr/Met + Met/Met 216 61 1.20 (0.60–2.39) 502 0.88 (0.65–1.18) 119 1.10 (0.71–1.71) 384 0.83 (0.61–1.13)
XPD Lys 751 Gln
Lys/Lys (AA) 148 43 1a 300 1a 69 1a 231 1a
Lys/Gln (AC) 142 47 0.81 (0.40–1.67) 390 1.35 (0.99–1.83) 86 1.27 (0.81–2.01) 304 1.33 (0.97–1.84)
Gln/Gln (CC) 41 15 1.00 (0.38–2.62) 136 1.66 (1.07–2.58) 34 1.59 (0.85–2.99) 102 1.61 (1.02–2.54)
Lys/Gln + Gln/Gln 183 62 0.86 (0.44–1.68) 526 1.42 (1.06–1.89) 120 1.35 (0.88–2.06) 406 1.40 (1.03–1.89)
Missing 1 1       1  
  1. a The genotype served as reference category
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BMC Cancer

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