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Table 3 Distributions of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln genotypes and development of colorectal carcinomas and adenomas. ORs are adjusted for age.

From: Polymorphisms of the XRCC1, XRCC3 and XPDgenes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study

Genotypes Controls Carcinomas OR (95% CI) Adenomas OR (95% CI) High-risk adenomas OR (95% CI) Low-risk adenomas OR (95% CI)
XRCC1Arg194Trp
Arg/Arg (CC) 352 135 1a 864 1a 197 1a 667 1a
Arg/Trp (CT) 46 19 0.99 (0.42–2.33) 115 1.07 (0.72–1.58) 29 1.35 (0.78–2.32) 86 0.99 (0.66–1.50)
Trp/Trp (TT) 1 2 - 4 - 1 - 3 -
Arg/Trp + Trp/Trp 47 21 1.00 (0.43–2.32) 119 1.09 (0.74–1.60) 30 1.38 (0.81–2.36) 89 1.01 (0.68–1.52)
Missing   1        
XRCC1 Arg 280 His
Arg/Arg (GG) 381 145 1a 906 1a 207 1a 699 1a
Arg/His (GA) 18 12 1.72 (0.58–5.04) 77 1.68 (0.96–2.93) 20 2.25 (1.10–4.60) 57 1.55 (0.87–2.76)
His/His (AA) 0 0 - 0 - 0 - 0 -
XRCC1 Arg 399 Gln
Arg/Arg (GG) 148 63 1a 391 1a 100 1a 291 1a
Arg/Gln (GA) 187 70 0.74 (0.41–1.33) 443 0.82 (0.62–1.08) 95 0.67 (0.46–0.99) 348 0.87 (0.65–1.16)
Gln/Gln (AA) 64 24 0.91 (0.42–1.98) 149 0.88 (0.61–1.29) 32 0.65 (0.38–1.13) 117 0.96 (0.65–1.42)
Arg/Gln + Gln/Gln 251 94 0.78 (0.45–1.35) 592 0.84 (0.64–1.08) 127 0.67 (0.46–0.96) 465 0.90 (0.68–1.17)
XRCC3 Thr 241 Met
Thr/Thr (CC) 138 64 1a 380 1a 88 1a 292 1a
Thr/Met (CT) 201 73 1.15 (0.64–2.08) 456 0.83 (0.63–1.10) 109 0.86 (0.58–1.27) 347 0.81 (0.61–1.09)
Met/Met (TT) 60 20 1.09 (0.46–2.55) 147 0.92 (0.63–1.35) 30 0.84 (0.48–1.47) 117 0.97 (0.65–1.45)
Thr/Met + Met/Met 261 93 1.14 (0.64–2.01) 603 1.11 (0.23–0.85) 139 0.86 (0.59–1.24) 464 0.85 (0.65–1.12)
XPD Lys 751 Gln
Lys/Lys (AA) 175 58 1a 364 1a 87 1a 277 1a
Lys/Gln (AC) 173 76 0.92 (0.52–1.63) 463 1.36 (1.03–1.78) 100 1.11 (0.75–1.63) 363 1.43 (1.07–1.89)
Gln/Gln (CC) 50 22 0.84 (0.36–1.95) 155 1.55 (1.05–2.30) 40 1.38 (0.80–2.37) 115 1.56 (1.03–2.36)
Lys/Gln + Gln/Gln 223 98 0.90 (0.52–1.54) 618 1.40 (1.08–1.81) 140 1.17 (0.81–1.68) 478 1.46 (1.11–1.90)
Missing 1 1   1     1  
  1. a The genotype served as reference category