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Table 3 Distributions of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln genotypes and development of colorectal carcinomas and adenomas. ORs are adjusted for age.

From: Polymorphisms of the XRCC1, XRCC3 and XPDgenes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study

Genotypes

Controls

Carcinomas

OR (95% CI)

Adenomas

OR (95% CI)

High-risk adenomas

OR (95% CI)

Low-risk adenomas

OR (95% CI)

XRCC1Arg194Trp

Arg/Arg (CC)

352

135

1a

864

1a

197

1a

667

1a

Arg/Trp (CT)

46

19

0.99 (0.42–2.33)

115

1.07 (0.72–1.58)

29

1.35 (0.78–2.32)

86

0.99 (0.66–1.50)

Trp/Trp (TT)

1

2

-

4

-

1

-

3

-

Arg/Trp + Trp/Trp

47

21

1.00 (0.43–2.32)

119

1.09 (0.74–1.60)

30

1.38 (0.81–2.36)

89

1.01 (0.68–1.52)

Missing

 

1

       

XRCC1 Arg 280 His

Arg/Arg (GG)

381

145

1a

906

1a

207

1a

699

1a

Arg/His (GA)

18

12

1.72 (0.58–5.04)

77

1.68 (0.96–2.93)

20

2.25 (1.10–4.60)

57

1.55 (0.87–2.76)

His/His (AA)

0

0

-

0

-

0

-

0

-

XRCC1 Arg 399 Gln

Arg/Arg (GG)

148

63

1a

391

1a

100

1a

291

1a

Arg/Gln (GA)

187

70

0.74 (0.41–1.33)

443

0.82 (0.62–1.08)

95

0.67 (0.46–0.99)

348

0.87 (0.65–1.16)

Gln/Gln (AA)

64

24

0.91 (0.42–1.98)

149

0.88 (0.61–1.29)

32

0.65 (0.38–1.13)

117

0.96 (0.65–1.42)

Arg/Gln + Gln/Gln

251

94

0.78 (0.45–1.35)

592

0.84 (0.64–1.08)

127

0.67 (0.46–0.96)

465

0.90 (0.68–1.17)

XRCC3 Thr 241 Met

Thr/Thr (CC)

138

64

1a

380

1a

88

1a

292

1a

Thr/Met (CT)

201

73

1.15 (0.64–2.08)

456

0.83 (0.63–1.10)

109

0.86 (0.58–1.27)

347

0.81 (0.61–1.09)

Met/Met (TT)

60

20

1.09 (0.46–2.55)

147

0.92 (0.63–1.35)

30

0.84 (0.48–1.47)

117

0.97 (0.65–1.45)

Thr/Met + Met/Met

261

93

1.14 (0.64–2.01)

603

1.11 (0.23–0.85)

139

0.86 (0.59–1.24)

464

0.85 (0.65–1.12)

XPD Lys 751 Gln

Lys/Lys (AA)

175

58

1a

364

1a

87

1a

277

1a

Lys/Gln (AC)

173

76

0.92 (0.52–1.63)

463

1.36 (1.03–1.78)

100

1.11 (0.75–1.63)

363

1.43 (1.07–1.89)

Gln/Gln (CC)

50

22

0.84 (0.36–1.95)

155

1.55 (1.05–2.30)

40

1.38 (0.80–2.37)

115

1.56 (1.03–2.36)

Lys/Gln + Gln/Gln

223

98

0.90 (0.52–1.54)

618

1.40 (1.08–1.81)

140

1.17 (0.81–1.68)

478

1.46 (1.11–1.90)

Missing

1

1

 

1

   

1

 
  1. a The genotype served as reference category