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Figure 8 | BMC Cancer

Figure 8

From: Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEAtransgene

Figure 8

Possible combinations of gastric tumor cell lines and mouse strains to generate mouse models which differ in the quality of the expressed tumor antigens and the anatomical location of the tumors. The quality of the potential tumor antigens Tag and CEA can be manipulated by ectopic transplantation of Tag and/or CEA-positive tumor cell lines in wild-type C57BL/6 mice, Tag- or Tag × CEA-transgenic mice. Depending on whether the proteins represent self or foreign antigens they can be regarded as TAA or TSA. In spontaneously developing autochthonous tumors both CEA and Tag represent TAA.

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