Figure 6

Growth of gastric carcinoma cell lines in wild-type and transgenic mice. 3 × 105 424GC cells were injected subcutaneously into C57BL/6 and CEA424/Tag-transgenic mice (A) or 3 × 105 mGC11^CEA cells were injected into C57BL/6 and CEA424/Tag × CEA-double transgenic mice (B). Tumor growth was quantified by two perpendicular measurements of the tumor diameter and calculation of the volume as described in the Materials and Methods section. Results are shown as mean +/- SD (n = 3).