Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cells

Table 3 Significantly overrepresented GO categories from the Panther annotation database using the same gene set as Table 1.

Biological Process	Observed Genes	Expected Genes	p-value
Cell structure and motility	175	118	3.6E-07
Cell communication	207	150	3.4E-06
Protein glycosylation	41	19	4.1E-06
Signal transduction	512	424	4.5E-06
Cell adhesion	107	68	5.6E-06
Carbohydrate metabolism	96	60	9.6E-06
Immunity and defense	220	166	2.5E-05
Protein modification	164	120	6.4E-05
Cell proliferation and differentiation	127	89	8.1E-05
Cell cycle	141	101	8.3E-05
Oncogenesis	101	69	1.6E-04
Cell structure	106	73	1.6E-04
Protein metabolism and modification	381	319	1.9E-04
Cell cycle control	75	49	2.3E-04
Developmental processes	304	249	2.4E-04
Extracellular matrix protein-mediated signaling	17	6	2.7E-04
Intracellular signaling cascade	138	103	4.1E-04
Tumor suppressor	26	13	0.001
Other polysaccharide metabolism	27	14	0.001
Apoptosis	81	57	0.001
Other metabolism	90	65	0.002
Receptor protein tyrosine kinase signaling pathway	36	21	0.002
Skeletal development	26	14	0.002
NF-kappaB cascade	18	8	0.003
Cell motility	52	35	0.003
Nucleoside, nucleotide and nucleic acid metabolism	441	390	0.004
Cell adhesion-mediated signaling	52	35	0.004
Mesoderm development	83	62	0.005
DNA replication	20	11	0.007
DNA metabolism	53	37	0.007
Lipid, fatty acid and steroid metabolism	105	82	0.008
Stress response	35	22	0.008

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