Figure 4From: Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cells (A) Plot of the average frequency of HES1 sites in genes upregulated by ST > 2-fold and in a random control list of 200 genes. (B) Sequence logo of the position weight matrix for HES1 sites based on the TRANSFAC database.(C) Immunoblot of whole cell lysates prepared from HEK-TERST and HEK-TERV cells and probed with antibodies specific for the activated human Notch-2. Activated Notch-2 is equally present in both cell lines (right), although longer exposures (left) reveal a shorter isoform that is more abundant in cells expressing SV40 ST.Back to article page