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Figure 4 | BMC Cancer

Figure 4

From: Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cells

Figure 4

(A) Plot of the average frequency of HES1 sites in genes upregulated by ST > 2-fold and in a random control list of 200 genes. (B) Sequence logo of the position weight matrix for HES1 sites based on the TRANSFAC database.(C) Immunoblot of whole cell lysates prepared from HEK-TERST and HEK-TERV cells and probed with antibodies specific for the activated human Notch-2. Activated Notch-2 is equally present in both cell lines (right), although longer exposures (left) reveal a shorter isoform that is more abundant in cells expressing SV40 ST.

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