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Table 2 Patient clinicopathological data and HER-4 membranous and cytoplasmic expression

From: Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas

 

HER-4 membranous expression

HER-4 cytoplasmic expression

Characteristic

(+) (n= 20)

(-) (n= 86)

p

(+) (n = 32)

(-) (n= 74)

P

Age Median (range)

64 (40 – 75)

63 (35 – 79)

0.906

64 (40 – 76)

63 (35 – 79)

0.656

Sex

Male

13 (65.0%)

53 (61.6%)

0.779

20 (62.5%)

46 (62.2%)

0.974

Female

7 (35.0%)

33 (38.4%)

 

12 (37.5%)

28 (37.8%)

 

Size

5 (1.6 – 8.5)

5 (1.5 – 12)

0.383

5 (2 – 10)

5 (1.5 – 12)

0.128

Lymph nodes status

(+)

19 (26.8%)

50 (60.2%)

0.003

25 (78.1%)

44 (62.0%)

0.107

(-)

1 (5.0%)

33 (39.8%)

 

7 (21.9%)

27 (38.0%)

 

Grade

Well

-

3 (3.5%)

0.999

-

3 (4.1%)

0.552

Moderate

17 (85.0%)

78 (90.7%)

0.431

31 (96.9%)

64 (86.5%)

0.167

Poor

3 (15.0%)

5 (5.8%)

0.171

1 (3.1%)

7 (9.5%)

0.430

Dukes' stage

B

1 (5.0%)

29 (33.7%)

0.010

7 (21.9%)

23 (31.1%)

0.334

C

11 (55.0%)

40 (46.5%)

0.494

14 (43.8%)

37 (50.0%)

0.554

D

8 (40.0%)

17 (19.8%)

0.078

11 (44.4%)

14 (18.9%)

0.085

Site

Proximal colon

4 (20.0%)

25 (29.1%)

0.412

11 (34.4%)

18 (24.3%)

0.287

Distal colon

9 (45.0%)

28 (75.7%)

0.293

11 (34.4%)

26 (35.1%)

0.940

Rectum

7 (61.6%)

33 (38.4%)

0.779

10 (31.2%)

30 (40.5%)

0.365