From: Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas
 | HER-4 membranous expression | HER-4 cytoplasmic expression | ||||
---|---|---|---|---|---|---|
Characteristic | (+) (n= 20) | (-) (n= 86) | p | (+) (n = 32) | (-) (n= 74) | P |
Age Median (range) | 64 (40 – 75) | 63 (35 – 79) | 0.906 | 64 (40 – 76) | 63 (35 – 79) | 0.656 |
Sex | ||||||
Male | 13 (65.0%) | 53 (61.6%) | 0.779 | 20 (62.5%) | 46 (62.2%) | 0.974 |
Female | 7 (35.0%) | 33 (38.4%) | Â | 12 (37.5%) | 28 (37.8%) | Â |
Size | 5 (1.6 – 8.5) | 5 (1.5 – 12) | 0.383 | 5 (2 – 10) | 5 (1.5 – 12) | 0.128 |
Lymph nodes status | ||||||
(+) | 19 (26.8%) | 50 (60.2%) | 0.003 | 25 (78.1%) | 44 (62.0%) | 0.107 |
(-) | 1 (5.0%) | 33 (39.8%) | Â | 7 (21.9%) | 27 (38.0%) | Â |
Grade | ||||||
Well | - | 3 (3.5%) | 0.999 | - | 3 (4.1%) | 0.552 |
Moderate | 17 (85.0%) | 78 (90.7%) | 0.431 | 31 (96.9%) | 64 (86.5%) | 0.167 |
Poor | 3 (15.0%) | 5 (5.8%) | 0.171 | 1 (3.1%) | 7 (9.5%) | 0.430 |
Dukes' stage | ||||||
B | 1 (5.0%) | 29 (33.7%) | 0.010 | 7 (21.9%) | 23 (31.1%) | 0.334 |
C | 11 (55.0%) | 40 (46.5%) | 0.494 | 14 (43.8%) | 37 (50.0%) | 0.554 |
D | 8 (40.0%) | 17 (19.8%) | 0.078 | 11 (44.4%) | 14 (18.9%) | 0.085 |
Site | ||||||
Proximal colon | 4 (20.0%) | 25 (29.1%) | 0.412 | 11 (34.4%) | 18 (24.3%) | 0.287 |
Distal colon | 9 (45.0%) | 28 (75.7%) | 0.293 | 11 (34.4%) | 26 (35.1%) | 0.940 |
Rectum | 7 (61.6%) | 33 (38.4%) | 0.779 | 10 (31.2%) | 30 (40.5%) | 0.365 |