|  | No.patients who experienced toxicity, at maximum grade per patient, at each dose level, mg/mq/die | |||||
---|---|---|---|---|---|---|---|
Toxicity | NCIC-CTC grade | 1500 | 1750 | 2000 | 2250 | 2500 | 2750 |
Nausea/vomiting | 0 | 2 | 3 | 2 | 2 | 5 | 4 |
 | 1 | 1 | 0 | 1 | 1 | 0 | 4 |
 | 2 | 0 | 0 | 0 | 0 | 1 | 1 |
 | 3* | 0 | 0 | 0 | 0 | 0 | 0 |
 | 4* | 0 | 0 | 0 | 0 | 0 | 0 |
Diarrhoea | 0 | 2 | 3 | 3 | 2 | 3 | 3 |
 | 1 | 1 | 0 | 0 | 0 | 1 | 4 |
 | 2 | 0 | 0 | 0 | 1 | 2 | 2 |
 | 3* | 0 | 0 | 0 | 0 | 0 | 0 |
 | 4* | 0 | 0 | 0 | 0 | 0 | 0 |
Liver Toxicity | 0 | 3 | 2 | 3 | 2 | 6 | 6 |
 | 1 | 0 | 1 | 0 | 1 | 0 | 3 |
 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
 | 3* | 0 | 0 | 0 | 0 | 0 | 0 |
 | 4* | 0 | 0 | 0 | 0 | 0 | 0 |
Stomatitis | 0 | 3 | 3 | 2 | 2 | 5 | 6 |
 | 1 | 0 | 0 | 1 | 1 | 1 | 3 |
 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
 | 3* | 0 | 0 | 0 | 0 | 0 | 0 |
 | 4* | 0 | 0 | 0 | 0 | 0 | 0 |
HFS | 0 | 3 | 2 | 3 | 2 | 4 | 4 |
 | 1 | 0 | 1 | 0 | 1 | 1 | 3 |
 | 2 | 0 | 0 | 0 | 0 | 1 | 2 |
 | 3* | 0 | 0 | 0 | 0 | 0 | 0 |
 | 4* | 0 | 0 | 0 | 0 | 0 | 0 |
Fatigue | 0 | 2 | 2 | 1 | 0 | 3 | 2 |
 | 1 | 0 | 1 | 2 | 2 | 1 | 4 |
 | 2 | 1 | 0 | 0 | 1 | 2 | 2 |
 | 3* | 0 | 0 | 0 | 0 | 0 | 0 |
 | 4* | 0 | 0 | 0 | 0 | 0 | 1 |
Leuco-neutropenia | 0 | 2 | 2 | 2 | 2 | 3 | 6 |
 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
 | 2 | 1 | 0 | 1 | 1 | 0 | 1 |
 | 3 | 0 | 0 | 0 | 0 | 1 | 1 |
 | 4* | 0 | 0 | 0 | 0 | 0 | 0 |
Thrombocytopenia | 0 | 2 | 3 | 2 | 3 | 5 | 6 |
 | 1 | 0 | 0 | 0 | 0 | 1 | 2 |
 | 2 | 1 | 0 | 1 | 0 | 0 | 1 |
 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
 | 4* | 0 | 0 | 0 | 0 | 0 | 0 |
Anemia | 0 | 1 | 2 | 1 | 2 | 3 | 7 |
 | 1 | 0 | 1 | 1 | 1 | 3 | 1 |
 | 2 | 2 | 0 | 1 | 0 | 0 | 1 |
 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
 | 4* | 0 | 0 | 0 | 0 | 0 | 0 |