Skip to main content

Table 3 Genotype frequencies of LEP and LEPR polymorphisms in relation to pathological indices of breast cancer severity.

From: Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma

Pathological feature   Number of patients (%) P-value
LEP(-2548) G/A GG GA + AA  
Tumor size
T1-T2 82 (42.05) 113 (57.95) 0.05
T3-T4 21 (26.92) 57 (73.08)  
Histological grade
1–2 68 (39.08) 106 (60.92) 0.3
3 28 (32.56) 58 (67.44)  
Lymph node metastases
Negative 64 (42.38) 87 (57.62) 0.13
Positive 51 (34.00) 99 (66.00)  
Hormone receptor status
Negative 34 (38.20) 55 (61.80) 0.36
Positive 77 (44.00) 98 (56.00)  
LEPR Q223R QQ QQ + RR  
Tumor size
T1-T2 56 (29.17) 136 (70.83) 0.57
T3-T4 27 (32.53) 56 (67.47)  
Histological grade
1–2 58 (32.95) 118 (67.05) 0.19
3 21 (25.00) 63 (75.00)  
Lymph node metastases
Negative 55 (36.67) 95 (63.33) 0.07
Positive 41 (27.15) 110 (72.85)  
Hormone receptor status
Negative 40 (41.53) 49 (58.47) 0.57
Positive 85 (34.33) 90 (65.67)  
  1. OR, odds ratio; CI, confidence interval. The χ2 test was used to determine whether significant differences (P-value) were observed when the patient group was compared with the control group. f, frequencies.