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Table 3 Genotype frequencies of LEP and LEPR polymorphisms in relation to pathological indices of breast cancer severity.

From: Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma

Pathological feature

 

Number of patients (%)

P-value

LEP(-2548) G/A

GG

GA + AA

 

Tumor size

T1-T2

82 (42.05)

113 (57.95)

0.05

T3-T4

21 (26.92)

57 (73.08)

 

Histological grade

1–2

68 (39.08)

106 (60.92)

0.3

3

28 (32.56)

58 (67.44)

 

Lymph node metastases

Negative

64 (42.38)

87 (57.62)

0.13

Positive

51 (34.00)

99 (66.00)

 

Hormone receptor status

Negative

34 (38.20)

55 (61.80)

0.36

Positive

77 (44.00)

98 (56.00)

 

LEPR Q223R

QQ

QQ + RR

 

Tumor size

T1-T2

56 (29.17)

136 (70.83)

0.57

T3-T4

27 (32.53)

56 (67.47)

 

Histological grade

1–2

58 (32.95)

118 (67.05)

0.19

3

21 (25.00)

63 (75.00)

 

Lymph node metastases

Negative

55 (36.67)

95 (63.33)

0.07

Positive

41 (27.15)

110 (72.85)

 

Hormone receptor status

Negative

40 (41.53)

49 (58.47)

0.57

Positive

85 (34.33)

90 (65.67)

 
  1. OR, odds ratio; CI, confidence interval. The χ2 test was used to determine whether significant differences (P-value) were observed when the patient group was compared with the control group. f, frequencies.