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Table 2 The LEP (-2548) G/A and LEPR Q223R Genotype distributions in Control Subjects and in Patients with Breast Carcinoma.

From: Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma

Genotypes Patients (n = 308) Controls (n = 222) OR Confidence interval P-value
  n f n f    
LEP ( -2548) G/A
GG 119 (0.386) 112 (0.504) 1   
GA 152 (0.494) 99 (0.446) 1.45 [0.99–2.11] 0.04
AA 37 (0.120) 11 (0.050) 3.17 [1.47–6.96] 0.001
Alleles
G-allele 390 (0.633) 323 (0.727)    
A-allele 226 (0.367) 121 (0.273) 1.55 [1.18–2.04] 0.001
LEPR Q223R
QQ 98 (0.318) 102 (0.460) 1   
QR 145 (0.471) 90 (0.405) 1.68 [1.12–2.50] 0.007
RR 65 (0.211) 30 (0.135) 2.26 [1.31–3.90] 0.001
Alleles
Q-allele 341 (0.554) 294 (0.662)    
R-allele 275 (0.446) 150 (0.338) 158 [1.22–2.05] 0.0003
  1. OR, odds ratio; CI, confidence interval. The χ2 test was used to determine whether significant differences (P-value) were observed when the patient group was compared with the control group. f, frequencies.