|
Genotypes
|
Patients (n = 308)
|
Controls (n = 222)
|
OR
|
Confidence interval
|
P-value
|
|---|
| |
n
|
f
|
n
|
f
| | | |
|
LEP (
-2548)
G/A
|
|
GG
|
119
|
(0.386)
|
112
|
(0.504)
|
1
| | |
|
GA
|
152
|
(0.494)
|
99
|
(0.446)
|
1.45
|
[0.99–2.11]
|
0.04
|
|
AA
|
37
|
(0.120)
|
11
|
(0.050)
|
3.17
|
[1.47–6.96]
|
0.001
|
|
Alleles
|
|
G-allele
|
390
|
(0.633)
|
323
|
(0.727)
| | | |
|
A-allele
|
226
|
(0.367)
|
121
|
(0.273)
|
1.55
|
[1.18–2.04]
|
0.001
|
|
LEPR Q223R
|
|
QQ
|
98
|
(0.318)
|
102
|
(0.460)
|
1
| | |
|
QR
|
145
|
(0.471)
|
90
|
(0.405)
|
1.68
|
[1.12–2.50]
|
0.007
|
|
RR
|
65
|
(0.211)
|
30
|
(0.135)
|
2.26
|
[1.31–3.90]
|
0.001
|
|
Alleles
|
|
Q-allele
|
341
|
(0.554)
|
294
|
(0.662)
| | | |
|
R-allele
|
275
|
(0.446)
|
150
|
(0.338)
|
158
|
[1.22–2.05]
|
0.0003
|
- OR, odds ratio; CI, confidence interval. The χ2 test was used to determine whether significant differences (P-value) were observed when the patient group was compared with the control group. f, frequencies.
