Table 3 Statistical analysis of cases with H63D mutation. Analysis between Total breast cancer patients and Healthy controls, Sporadic breast cancer patients and Healthy controls, Familial breast cancer patients and Healthy controls, Sporadic breast cancer and Familial breast cancer patients, Premenopausal and Postmenopausal breast cancer patients are shown. One healthy volunteer was homozygous for the mutation; all other subjects listed here were heterozygous. All the subjects studied were free from C282Y mutation.
From: HFE H63D mutation frequency shows an increase in Turkish women with breast cancer
| Â | Cases with H63D mutation | P value (two-sided) | Odds ratio (OR) | %95 Confidence Interval-CI- (using the approximation of Woolf) |
|---|---|---|---|---|
Total breast cancer patients: Healthy controls | 39/88: 28/100 | 0.02 | 2.05 | 1.12 to 3.75 |
Sporadic breast cancer patients: Healthy controls | 31/71: 28/100 | 0.05 | 2 | 1.05 to 3.78 |
Familial breast cancer patients: Healthy controls | 8/17: 28/100 | 0.15 | 2.29 | 0.80 to 6.52 |
Sporadic breast cancer patients: Familial breast cancer patients | 31/71: 8/17 | 1 | 1.15 | 0.4 to 3.32 |
Premenopausal breast cancer patients: Post menopausal breast cancer patients | 22/57: 5/7 | 0.12 | 0.25 | 0.04 to 1.41 |