Parameter (unit) | n | Geomean | Min | Max |
|---|
Cmax (ng/mL) | 11 | 61163 | 50100 | 85500 |
tmax (h) | 11 | 1* | 1 | 1.25 |
AUC0-t (ng/mL*h) | 11 | 182069 | 128234 | 334829 |
AUC0-∝ (ng/mL*h) | 10 | 183968 | 134307 | 243990 |
λz (1/h) | 10 | 0.230 | 0.155 | 0.278 |
t1/2 (h) | 10 | 3.0 | 2.5 | 4.5 |
CL (mL/min/m2) | 10 | 54.2 | 41.0 | 72.5 |
Vss (mL/m2) | 10 | 12100 | 8299 | 16384 |
- Data are pharmacokinetic parameters of Cilengitide one hour after an intravenous infusion.
- *Median is given.
- Abbreviations are: n, number; Geomean, geometric mean; Min, minimum; Max, maximum; Cmax, the observed maximum plasma concentration; tmax, time to reach Cmax; AUC, area under the curve; λz, apparent first-order rate constant; t1/2, apparent terminal half-life associated with negative terminal slope; CL, total body clearance of drug from plasma; Vss, volume of distribution at steady state.
