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Figure 5 | BMC Cancer

Figure 5

From: Anti-vascular agent Combretastatin A-4-P modulates Hypoxia Inducible Factor-1 and gene expression

Figure 5

CA-4-P-modulation of the angiogenic growth factor VEGF. Expression of VEGF was detected by real time RT-PCR in T24 bladder carcinoma (A) and HUVEC (B) following aerobic treatment: (1) control, (2) 2 h CA-4-P (1 μM), (3) 24 h CA-4-P (1 μM), (4) 4 h CoCl2 (100 μM), (5) 24 h CA-4-P and 4 h CoCl2. RNA was extracted from two flasks each, and > 3 independent real time PCR reactions were performed on each; average and SEM are shown; * p < 0.05 compared to control; # p < 0.05 compared to (3).

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