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Table 3 Altered fractionated radiotherapy with or without chemotherapy using combinations of 5-FU with cisplatin or mitomycin C; only trials with a relevant prolongation in overall treatment time, caused by planned split course treatment or rapidly alternating radiochemotherapy (Imbalanced-RT, group 1c)

From: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck

  

control arm

experimental arm

  

publication

trial #

Dose [Gy]

RT time [days]

Dose [Gy]

RT time [days]

DDP

Carbo

5-FU

FA

MMC

Stage 4 [%]

N3 [%]

Keane [38] CF split

17

50

28

50

56

  

8000

 

20

47

17

Corvo [39] alter. CF

18

75

42

60

56

400

 

4000

  

82

12

Merlano [40] alter. CF

19

70

49

60

56

400

 

4000

  

75

31

  1. DDP = cisplatin cumulative dose [mg/m2]; Carbo = carboplatin cumulative dose [mg/m2]; 5-FU = 5-fluorouracil cumulative dose [mg/m2]; FA = folinic acid; MMC = mitomycin C cumulative dose [mg/m2]