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Table 3 Altered fractionated radiotherapy with or without chemotherapy using combinations of 5-FU with cisplatin or mitomycin C; only trials with a relevant prolongation in overall treatment time, caused by planned split course treatment or rapidly alternating radiochemotherapy (Imbalanced-RT, group 1c)

From: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck

   control arm experimental arm   
publication trial # Dose [Gy] RT time [days] Dose [Gy] RT time [days] DDP Carbo 5-FU FA MMC Stage 4 [%] N3 [%]
Keane [38] CF split 17 50 28 50 56    8000   20 47 17
Corvo [39] alter. CF 18 75 42 60 56 400   4000    82 12
Merlano [40] alter. CF 19 70 49 60 56 400   4000    75 31
  1. DDP = cisplatin cumulative dose [mg/m2]; Carbo = carboplatin cumulative dose [mg/m2]; 5-FU = 5-fluorouracil cumulative dose [mg/m2]; FA = folinic acid; MMC = mitomycin C cumulative dose [mg/m2]