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Table 1 Conventionally fractionated radiotherapy with or without simultaneous chemotherapy using cisplatin, carboplatin, mitomycin C, and 5-FU as single drug or combinations of 5-FU with platinum-derivate (group 1a)

From: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck

   control arm experimental arm   
publication trial # dose [Gy] RT time [days] dose [Gy] RT time [days] DDP Carbo 5-FU FA MMC stage 4 [%] neck N3 [%]
Sanchiz [18] 1 60 42.0 60 42.0    3750     30
Lo [24] 2 66 56.0 66 56.0    5500    41 38
Browman [25] 3 66 45.5 66 45.5    7200    55 14
Jerimic [26] 4 70 50.8 70 50.8 222      86 16
Adelstein [27] 5 70 49.0 70 49.0 300      94 28
Jeremic [26] 6 70 50.8 70 50.8   925     86 19
Grau [28] 7 66 47.0 66 47.0      30 53 4
Adelstein [29] 8 70 49.0 70 49.0 160   8000    72 31
Olmi [30] 9 68 47.3 68 47.25   900 12000    75 7
Denis, Calais [31,32] 10 70 49.0 70 49.0   840 7200    68 13
  1. DDP = cisplatin cumulative dose [mg/m2]; Carbo = carboplatin cumulative dose [mg/m2]; 5-FU = 5-fluorouracil cumulative dose [mg/m2]; FA = folinic acid; MMC = mitomycin C cumulative dose [mg/m2]