Difference of median survival with different drugs used for concomitant radiochemotherapy compared to radiotherapy alone, χ2 = > p-value = 0.04. 5-fluorouracil: studies with simultaneus 5-fluorouracil chemotherapy [18,24,25,38]. Cisplatin: studies with simultaneus cisplatin based chemotherapy [26,27,29,33,34,35,39,40]. Carboplatin: studies with simultaneus carboplatin based chemotherapy [26,30,31,32,36]. Mitomycin C: studies with mitomycin C based chemotherapy [12,30,37]. LCL = 95% lower confidence limit, UCL = 95% upper confidence limit; N = number of patients.