Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation

BMC Cancer

Table 1 Phosphorylation and expression of the molecules and their relationship to gefitinib sensitivity

Expression of the molecules: (+) positive; (-) negative	P
Phosphorylated Akt/Akt (+)	0.0059**
PTEN/β-actin (+)	0.361
phospho-p44/42/p44/42 (+)	0.852
phospho-p38/p38 (+)	>0.99
phospho-EGFR/EGFR (+)	0.0319**
Her2/β-actin (+)	0.0344**
Her3/β-actin(+)	0.5582
phospho-EGFR(+) phospho-Akt(+)	0.0344**
(vs phospho-EGFR(-) or phospho-Akt(-))

The relationship between gefitinib-sensitivity and the expression of these molecules was investigated by the Chi-square test. **P < 0.05 was considered to be statistically significant.

ISSN: 1471-2407