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Table 1 Phosphorylation and expression of the molecules and their relationship to gefitinib sensitivity

From: Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation

Expression of the molecules: (+) positive; (-) negative P
Phosphorylated Akt/Akt (+) 0.0059**
PTEN/β-actin (+) 0.361
phospho-p44/42/p44/42 (+) 0.852
phospho-p38/p38 (+) >0.99
phospho-EGFR/EGFR (+) 0.0319**
Her2/β-actin (+) 0.0344**
Her3/β-actin(+) 0.5582
phospho-EGFR(+) phospho-Akt(+) 0.0344**
(vs phospho-EGFR(-) or phospho-Akt(-))  
  1. The relationship between gefitinib-sensitivity and the expression of these molecules was investigated by the Chi-square test. **P < 0.05 was considered to be statistically significant.