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Figure 4 | BMC Cancer

Figure 4

From: Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation

Figure 4

Summary of expression of Her3 and phosphorylation of p44/42 MAPK in 23 lung cancer cell lines grown under serum-containing (cross bars) and serum-free (black bars) conditions. (A) the ratio of phosphorylated p44/42 MAPK signal/total p44/42MAPK signal (MAPKp-p44/42/MAPKp44/42); (B) the ratio of Her3 signal/β-actin signal; The density of expression of each of the molecules was measured by NIH Image. Point: mean of three independent experiment; bars, ± standard deviation (SD). The expression ratio of the molecules in serum-free conditions was compared between gefitinib-resistant and gefitinib-sensitive cell lines using the Mann-Whitney test; point, mean, bars, ± standard error (SE). *P < 0.05 was considered to be statistically significant.

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