Table 3 Quality of life mean score changes before and after 3 cycles of chemotherapy (follow-up scores minus baseline scores) for each study arms

Physical functioning

4.1 (13.6)

0.08

2.3 (14.8)

0.36

Role functioning

0.57 (14.3)

0.81

2.7 (18.9)

0.38

Emotional functioning

-0.06 (8.3)

0.96

8.0 (15.4)

0.004

Cognitive functioning

-2.5 (13.4)

0.27

-6.1 (17.0)

0.04

Social functioning

-2.3 (14.6)

0.36

5.2 (14.1)

0.03

Global quality of life

2.4 (14.5)

0.34

9.7 (16.8)

0.001

Symptom scores ²

Fatigue

-0.99 (14.8)

0.69

-4.6 (14.1)

0.05

Nausea and vomiting

-3.5 (19.6)

0.29

-1.4 (29.9)

0.78

Pain

-6.3 (14.2)

0.01

-5.7 (15.1)

0.03

Dyspnoea

-2.6 (14.9)

0.31

-0.92 (20.3)

0.78

Sleep difficulties

-5.8 (23.5)

0.15

-11.3 (27.5)

0.02

Appetite loss

-4.6 (19.8)

0.17

-5.4 (29.3)

0.27

Constipation

-1.1 (29.4)

0.83

0.92 (36.9)

0.88

Diarrhoea

9.8 (19.0)

0.004

0.32 (27.6)

0.94

Financial difficulties

9.1 (23.6)

0.03

11.6 (19.3)

0.001