Table 4 Association between genotypes of MMP and colorectal adenomas
From: Genetic polymorphisms of MMP1, MMP3 and MMP7gene promoter and risk of colorectal adenoma
Large adenoma patients (LA) | Polyp free controls (PF) | Small adenoma patients (SA) | LA vs PF | LA vs SA | SA vs PF | ||||
|---|---|---|---|---|---|---|---|---|---|
OR* (95%CI) | P** | OR* (95%CI) | P** | OR* (95%CI) | P** | ||||
MMP1 | |||||||||
1G/1G | 81 | 154 | 81 | 1 | 1 | 1 | |||
1G/2G | 139 | 285 | 139 | 0.94 (0.66–1.33) | 1.04 (0.69–1.56) | 0.96 (0.67–1.37) | |||
2G/2G | 72 | 122 | 79 | 1.18 (0.78–1.78) | 0.491 | 0.90 (0.56–1.43) | 0.792 | 1.22 (0.81–1.84) | 0.431 |
MMP3.1 | |||||||||
5A/5A | 70 | 130 | 68 | 1 | 1 | 1 | |||
5A/6A | 139 | 291 | 132 | 0.87 (0.60–1.25) | 1.10 (0.72–1.69) | 0.85 (0.58–1.24) | |||
6A/6A | 73 | 126 | 93 | 1.11 (0.73–1.69) | 0.391 | 0.78 (0.48–1.25) | 0.250 | 1.50 (0.99–2.28) | 0.008 |
MMP3.2 | |||||||||
AA | 182 | 358 | 194 | 1 | 1 | 1 | |||
AG | 105 | 187 | 92 | 1.10 (0.81–1.50) | 1.20 (0.83–1.73) | 0.87 (0.64–1.20) | |||
GG | 7 | 19 | 16 | 0.72 (0.29–1.78) | 0.615 | 0.49 (0.19–1.27) | 0.175 | 1.34 (0.65–2.75) | 0.464 |
MMP7 | |||||||||
AA | 92 | 187 | 99 | 1 | 1 | 1 | |||
AG | 138 | 259 | 136 | 1.08 (0.77–1.50) | 1.06 (0.72–1.56) | 0.98 (0.70–1.38) | |||
GG | 64 | 119 | 67 | 1.17 (0.78–1.77) | 0.742 | 1.08 (0.67–1.72) | 0.944 | 1.14 (0.76–1.71) | 0.746 |