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Table 4 Association between genotypes of MMP and colorectal adenomas

From: Genetic polymorphisms of MMP1, MMP3 and MMP7gene promoter and risk of colorectal adenoma

  Large adenoma patients (LA) Polyp free controls (PF) Small adenoma patients (SA) LA vs PF   LA vs SA   SA vs PF  
     OR* (95%CI) P** OR* (95%CI) P** OR* (95%CI) P**
MMP1          
1G/1G 81 154 81 1   1   1  
1G/2G 139 285 139 0.94 (0.66–1.33)   1.04 (0.69–1.56)   0.96 (0.67–1.37)  
2G/2G 72 122 79 1.18 (0.78–1.78) 0.491 0.90 (0.56–1.43) 0.792 1.22 (0.81–1.84) 0.431
MMP3.1          
5A/5A 70 130 68 1   1   1  
5A/6A 139 291 132 0.87 (0.60–1.25)   1.10 (0.72–1.69)   0.85 (0.58–1.24)  
6A/6A 73 126 93 1.11 (0.73–1.69) 0.391 0.78 (0.48–1.25) 0.250 1.50 (0.99–2.28) 0.008
MMP3.2          
AA 182 358 194 1   1   1  
AG 105 187 92 1.10 (0.81–1.50)   1.20 (0.83–1.73)   0.87 (0.64–1.20)  
GG 7 19 16 0.72 (0.29–1.78) 0.615 0.49 (0.19–1.27) 0.175 1.34 (0.65–2.75) 0.464
MMP7          
AA 92 187 99 1   1   1  
AG 138 259 136 1.08 (0.77–1.50)   1.06 (0.72–1.56)   0.98 (0.70–1.38)  
GG 64 119 67 1.17 (0.78–1.77) 0.742 1.08 (0.67–1.72) 0.944 1.14 (0.76–1.71) 0.746
  1. * OR adjusted on age, sex, and group of centres
  2. ** P: p-value for the Wald test assessing the global effect of SNP, uncorrected for multiple testing