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Table 2 Sensitivity of MCA (*≥11 or **≥15 U/mL cut-off values)-CA15.3 and CEA-TPA-CA15.3 panels in the early detection of 19 relapses during an intensive post-operative follow-up with tumour markers.

From: Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection of distant metastases

  CE or PI of tumour markers as the initial pathological finding of relapse
Tumour marker association aRelapses (total, n) Sensitivity (%) Tumour marker increase Lead time (months) m + sd (range)
    type n  
*MCA-CA15.3 13 68 CE PI 8 5 7.1 ± 6.8 (0–22)
CEA-TPA-CA15.3 10 53 CE PI 5 5 3.9 ± 4.9 (0–14)
**MCA-CA15.3 11 58 CE PI 8 3 5.9 ± 6.7 (0–18)
CEA-TPA-CA15.3 14 74 CE PI 8 6 4.6 ± 5.9 (0–18)
  1. aTotal number of patients = 18; one patient after radical removal by surgery of a single metastatic lesion relapsed (also see Result section). Therefore, percentages are calculated on 19 relapses; CE = constant elevation; PI = progressive increase.