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Table 2 Sensitivity of MCA (*≥11 or **≥15 U/mL cut-off values)-CA15.3 and CEA-TPA-CA15.3 panels in the early detection of 19 relapses during an intensive post-operative follow-up with tumour markers.

From: Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection of distant metastases

 

CE or PI of tumour markers as the initial pathological finding of relapse

Tumour marker association

aRelapses

(total, n)

Sensitivity

(%)

Tumour marker increase

Lead time (months)

m + sd (range)

   

type

n

 

*MCA-CA15.3

13

68

CE

PI

8 5

7.1 ± 6.8

(0–22)

CEA-TPA-CA15.3

10

53

CE

PI

5 5

3.9 ± 4.9

(0–14)

**MCA-CA15.3

11

58

CE

PI

8 3

5.9 ± 6.7

(0–18)

CEA-TPA-CA15.3

14

74

CE

PI

8 6

4.6 ± 5.9

(0–18)

  1. aTotal number of patients = 18; one patient after radical removal by surgery of a single metastatic lesion relapsed (also see Result section). Therefore, percentages are calculated on 19 relapses; CE = constant elevation; PI = progressive increase.