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Table 1 Genotype and allele frequencies of rs12255372 in unrelated female German BRCA1/2 mutation-negative familial breast cancer (BC) patients and healthy, unrelated female control subjects

From: Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study

Genotype BC Case Patients N (%) Control Subjects N (%) OR [95% C.I.], Pvaluea
GG 297 (50.2) 408 (55.5) 1.00
GT 244 (41.2) 276 (37.6) 1.21 [0.97, 1.53], 0.09
TT 51 (8.6) 51 (6.9) 1.37 [0.91, 2.08], 0.13
GT+TT 295 (49.8) 327 (44.5) 1.24 [1.00, 1.54], 0.05
Allele    
G 0.71 0.74 1.00
T 0.29 0.26 1.19 [1.01, 1.42], 0.04
Cochran-Armitage trend test P trend = 0.04  
  1. aOdds ratios (OR) with 95% confidence intervals (95% C.I.) and respective P values were computed by unconditional logistic regression using the Statistical Analysis System software (SAS version 9.1.; SAS Institute Inc., Cary, NC). Adjustment for age did not change the ORs, assuming that the distribution of the TCF7L2 rs12255372 genotypes is age-independent.