Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study

Table 1 Genotype and allele frequencies of rs12255372 in unrelated female German BRCA1/2 mutation-negative familial breast cancer (BC) patients and healthy, unrelated female control subjects

Genotype	BC Case Patients N (%)	Control Subjects N (%)	OR [95% C.I.], Pvalue^a
GG	297 (50.2)	408 (55.5)	1.00
GT	244 (41.2)	276 (37.6)	1.21 [0.97, 1.53], 0.09
TT	51 (8.6)	51 (6.9)	1.37 [0.91, 2.08], 0.13
GT+TT	295 (49.8)	327 (44.5)	1.24 [1.00, 1.54], 0.05
Allele
G	0.71	0.74	1.00
T	0.29	0.26	1.19 [1.01, 1.42], 0.04
Cochran-Armitage trend test	P _trend = 0.04

^aOdds ratios (OR) with 95% confidence intervals (95% C.I.) and respective P values were computed by unconditional logistic regression using the Statistical Analysis System software (SAS version 9.1.; SAS Institute Inc., Cary, NC). Adjustment for age did not change the ORs, assuming that the distribution of the TCF7L2 rs12255372 genotypes is age-independent.

ISSN: 1471-2407