Figure 2From: A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo(A) Effect of in vivo CuNG treatment on ROS generation in heart, kidney, liver and lung of normal and EAC/Dox bearing mice. Results are presented as mean ± S.D. of 4 independent experiments, each involving 3 animals in each experimental group. Compared to untreated EAC/Dox bearing animals, In vivo CuNG treatment significantly increased ROS generation in kidney and liver, while decreased ROS generation in heart and lungs (*, P < 0.005 and **, P < 0.01). (B) Effect of in vivo CuNG treatment on SOD, catalase and GPx activity in heart, kidney, liver and lung of normal and EAC/Dox bearing mice. Results are presented as mean ± S.D. of 5 independent experiments, each involving 4 animals in each experimental group. Compared to untreated EAC/Dox bearing animals, In vivo CuNG treatment significantly increased SOD activity in heart, kidney and lungs, while increased catalase activity in heart, kidney and liver (*, P < 0.005 and **, P < 0.01).Back to article page