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Figure 2 | BMC Cancer

Figure 2

From: A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo

Figure 2

(A) Effect of in vivo CuNG treatment on ROS generation in heart, kidney, liver and lung of normal and EAC/Dox bearing mice. Results are presented as mean ± S.D. of 4 independent experiments, each involving 3 animals in each experimental group. Compared to untreated EAC/Dox bearing animals, In vivo CuNG treatment significantly increased ROS generation in kidney and liver, while decreased ROS generation in heart and lungs (*, P < 0.005 and **, P < 0.01). (B) Effect of in vivo CuNG treatment on SOD, catalase and GPx activity in heart, kidney, liver and lung of normal and EAC/Dox bearing mice. Results are presented as mean ± S.D. of 5 independent experiments, each involving 4 animals in each experimental group. Compared to untreated EAC/Dox bearing animals, In vivo CuNG treatment significantly increased SOD activity in heart, kidney and lungs, while increased catalase activity in heart, kidney and liver (*, P < 0.005 and **, P < 0.01).

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