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Table 2 Breakdown of patient outcome by patient characteristics

From: Barriers in phase I cancer clinical trials referrals and enrollment: five-year experience at the Princess Margaret Hospital

  

N

Entered on Trial (% of Row Total)

Ineligible (% of Row Total)

Refused (% of Row Total)

Other Treatment Suggested First/No Spots Available/Initially Eligible but Deteriorated (% of Row Total)

Doing Well, Treat when Progress/Unclear/Lost (% of Row Total)

N

 

667

29.5

24.7

14.4

24.9

6.5

Age

Mean (sd)^

667

56.6 (10.3)

57.3 (11.5)

57.8 (11.3)

54.3 (10.4)

58.4 (14.0)

 

% 70+

75

21.3

30.7

17.3

16.0

14.7

 

%<70

592

30.6

24.0

14.0

26.0

5.4

Distance from PMH (km)

Median [IQR]^

667

21.9 [12.6–38.2]

21.7 [14.2–42.7]

20.7 [12.6–35.5]

28.2 [12.6–57.6]

22.2 [12.7–59.5]

Gender

Male

339

30.1

23.9

12.7

26.0

7.4

 

Female

328

29.0

25.6

16.2

23.8

5.5

Tumor site

Breast

46

23.9

39.1

15.2

19.6

2.2

 

GI colorectal

172

23.8

25.0

14.0

30.2

7.0

 

GI non-colorectal

178

33.7

22.5

16.3

20.8

6.7

 

Genitourinary

36

30.6

27.8

13.9

19.4

8.3

 

Gynaecologic

74

44.6

17.6

13.5

23.0

1.4

 

Head and neck

23

56.5

4.4

13.0

17.4

8.7

 

Lung

57

17.5

24.6

10.5

38.6

8.8

 

Sarcoma

8

12.5

37.5

12.5

25.0

12.5

 

Skin/melanoma

11

27.3

27.3

9.1

18.2

18.2

 

Unknown primary

42

26.2

26.2

14.3

26.2

7.1

 

Multiple sites

6

0.0

100.0

0.0

0.0

0.0

 

Other

14

21.4

21.4

28.6

21.4

14.3

Number of prior regimens

0

68

47.1

20.6

14.7

14.7

2.9

 

1

210

32.9

20.5

14.8

25.7

6.2

 

2

186

24.2

25.3

14.5

26.9

9.1

 

3+

203

25.1

30.1

13.8

25.6

5.4

ECOG

0

211

43.6

9.0

16.1

24.2

7.1

 

1

318

28.6

17.3

16.0

29.6

8.5

 

2

87

14.9

49.4

12.6

21.8

1.2

 

3+

51

2.0

94.1

0.0

3.9

0.0

Referring physician

PMH Oncologists

328

38.4

21.3

15.9

21.3

3.1

 

External Oncologists

310

19.0

29.4

12.6

29.0

10.0

 

Others/Unknown

29

41.4

13.8

17.2

20.7

6.9

  1. ^ Entries in these rows are in units as listed