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Table 2 Breakdown of patient outcome by patient characteristics

From: Barriers in phase I cancer clinical trials referrals and enrollment: five-year experience at the Princess Margaret Hospital

   N Entered on Trial (% of Row Total) Ineligible (% of Row Total) Refused (% of Row Total) Other Treatment Suggested First/No Spots Available/Initially Eligible but Deteriorated (% of Row Total) Doing Well, Treat when Progress/Unclear/Lost (% of Row Total)
N   667 29.5 24.7 14.4 24.9 6.5
Age Mean (sd)^ 667 56.6 (10.3) 57.3 (11.5) 57.8 (11.3) 54.3 (10.4) 58.4 (14.0)
  % 70+ 75 21.3 30.7 17.3 16.0 14.7
  %<70 592 30.6 24.0 14.0 26.0 5.4
Distance from PMH (km) Median [IQR]^ 667 21.9 [12.6–38.2] 21.7 [14.2–42.7] 20.7 [12.6–35.5] 28.2 [12.6–57.6] 22.2 [12.7–59.5]
Gender Male 339 30.1 23.9 12.7 26.0 7.4
  Female 328 29.0 25.6 16.2 23.8 5.5
Tumor site Breast 46 23.9 39.1 15.2 19.6 2.2
  GI colorectal 172 23.8 25.0 14.0 30.2 7.0
  GI non-colorectal 178 33.7 22.5 16.3 20.8 6.7
  Genitourinary 36 30.6 27.8 13.9 19.4 8.3
  Gynaecologic 74 44.6 17.6 13.5 23.0 1.4
  Head and neck 23 56.5 4.4 13.0 17.4 8.7
  Lung 57 17.5 24.6 10.5 38.6 8.8
  Sarcoma 8 12.5 37.5 12.5 25.0 12.5
  Skin/melanoma 11 27.3 27.3 9.1 18.2 18.2
  Unknown primary 42 26.2 26.2 14.3 26.2 7.1
  Multiple sites 6 0.0 100.0 0.0 0.0 0.0
  Other 14 21.4 21.4 28.6 21.4 14.3
Number of prior regimens 0 68 47.1 20.6 14.7 14.7 2.9
  1 210 32.9 20.5 14.8 25.7 6.2
  2 186 24.2 25.3 14.5 26.9 9.1
  3+ 203 25.1 30.1 13.8 25.6 5.4
ECOG 0 211 43.6 9.0 16.1 24.2 7.1
  1 318 28.6 17.3 16.0 29.6 8.5
  2 87 14.9 49.4 12.6 21.8 1.2
  3+ 51 2.0 94.1 0.0 3.9 0.0
Referring physician PMH Oncologists 328 38.4 21.3 15.9 21.3 3.1
  External Oncologists 310 19.0 29.4 12.6 29.0 10.0
  Others/Unknown 29 41.4 13.8 17.2 20.7 6.9
  1. ^ Entries in these rows are in units as listed