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Table 4 MTHFR C677T and breast cancer survival

From: Association of MTHFR gene polymorphisms with breast cancer survival

  Person-years1 # events2 HR (95% CI)3 p-value
C677T genotype (n = 198)     
   C/C    1  
   C/T or T/T 873 46 0.65 (0.31–1.35) 0.25
ER-negative (n = 84)     
   C/C    1  
   C/T or T/T 352 29 0.36 (0.12–1.04) 0.06
ER-positive (n = 114)     
   C/C    1  
   C/T or T/T 521 17 1.12 (0.35–3.59) 0.82
African-American (n = 121)     
   C/C    1  
   C/T or T/T 520 29 0.12 (0.02–0.92) 0.04
Caucasian (n = 77)     
   C/C    1  
   C/T or T/T 352 17 1.89 (0.57–6.32) 0.3
No Chemotherapy (n = 81)     
   C/C    1  
   C/T or T/T 394 13 0.88 (0.21–3.74) 0.87
Chemotherapy (n = 117)     
   C/C    1  
   C/T or T/T 479 33 0.55 (0.22–1.34) 0.19
  1. 1 Time at risk in person-years. 2 Number of deaths due to breast cancer. 3 Cox Proportional-Hazards regression with adjustments for age at diagnosis, race, A1298C, BMI, estrogen receptor, TNM stage, and chemotherapy.
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