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Table 2 Distribution of C677T and A1298C genotypes by race/ethnicity1

From: Association of MTHFR gene polymorphisms with breast cancer survival

 

African-American n (%)

Caucasian n (%)

p-value2

Combined n (%)

C677T

    

   C/C

114 (81)

49 (48)

< 0.001

163 (67)

   C/T

27 (19)

44 (43)

 

71 (29)

   T/T

0

9 (9)

 

9 (4)

A1298C

    

   A/A

98 (69)

37 (36)

< 0.001

135 (56)

   A/C

38 (27)

49 (48)

 

87 (36)

   C/C

5 (4)

16 (16)

 

21 (8)

  1. 1 Only cases who were successfully genotyped for both SNPs (n = 243) are included
  2. 2 Chi-square test comparing genotype distributions between African-Americans and Caucasians