Table 1 Clinico-pathological and genetic data of 41 neuroblastic tumors.
From: Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma
Tumor | Age | Sex | Localization | Diagnosis | Shimada Histology | Ki 67 | LOH 1p | MYCN amp. |
|---|---|---|---|---|---|---|---|---|
1 | 3 y | M | Mediastinum | GN | n.a. | 1% | n.a. | n.a. |
17 | 13 y | M | Mediastinum | GN | Stroma rich. Dif. Low MKI. | 1% | n.a. | n.a. |
94 | 4 y | M | Suprarenal | GN | Stroma rich. Dif. Low MKI. | 15% | n.a. | n.a. |
3 | 5 y | M | Suprarenal | GNB | Stroma rich. Dif. Low MKI. | 5% | n.a. | n.a. |
5 | 3 y | F | Suprarenal | GNB | Stroma rich. Nodular | 5% | NO | NO |
7 | 3 y | F | Retroperitoneum | GNB | Stroma rich. Mixed | 2% | NO | NO |
8 | 1 y | F | Suprarenal | GNB | Stroma rich. Nodular | n.a. | NO | YES (10 copies) |
9 | 7 y | M | n.a. | GNB | Stroma rich. Dif. Low MKI. | 10% | NO | NO |
10 | 4 y | M | Retroperitoneum | GNB | Stroma rich. Dif. Mild MKI. | 15% | YES | NO |
61 | 1 y | F | Mediastinum | GNB | Stroma rich. Dif. Low MKI. | 10% | n.a. | NO |
82 | 2 y | M | Retroperitoneum | GNB | Stroma rich. Nodular | n.a. | NO | NO |
83 | 6 y | V | Mediastinum | GNB | Stroma rich. Nodular | 15% | NO | NO |
86 | 2 y | F | Retroperitoneum | GNB | Stroma rich. Dif. Low MKI. | 15% | n.a. | YES (10–50 copies) |
92 | 6 y | M | Mediastinum | GNB | Stroma rich. Nodular | 15% | NO | NO |
107 | 1 y | M | Thoracic-abdominal | GNB | Stroma rich. Mixed | 5% | YES | NO |
12 | 2 m | F | Suprarenal | NB | Stroma poor. Undif. Mild MKI. | 50% | NO | YES (20 copies) |
13 | 11 m | M | Abdominal | NB | Stroma poor. Undif. High MKI. | 60% | NO | NO |
14 | 2 y | M | Retroperitoneum | NB | Stroma poor. Dif. Low MKI. | 40–50% | YES | YES (50 copies) |
15 | 3 y | M | Suprarenal | NB | Stroma poor. Dif. Mild MKI. | 40–50% | NO | NO |
16 | 9 y | M | Mediastinum | NB | Stroma poor. Undif. High MKI. | 60% | NO | NO |
18 | 6 y | F | Thoracic-abdominal | NB | Stroma poor. Undif. Mild MKI. | 60% | YES | NO |
33 | 9 y | M | Suprarenal | NB | Stroma poor. Undif. High MKI. | 70% | NO | NO |
37 | 2 w | F | Retroperitoneum | NB | Stroma Poor. Undif. Low MKI. | 10% | NO | NO |
34 | 2 m | F | Mediastinum | NB | Stroma poor. Dif. | 15% | YES | NO |
45 | 3 w | F | Suprarenal | NB | Stroma poor. Undif. Low MKI. | 10% | YES | NO |
48 | 7 m | F | Paraaortic | NB | Stroma rich. Dif Low MKI. | 5% | n.a. | NO |
51 | 4 w | M | Suprarenal | NB | Stroma poor. Dif. | 20% | NO | NO |
52 | 1 m | F | Suprarenal | NB | Stroma poor. Undif. Low MKI. | 10% | n.a. | NO |
63 | 5 m | M | Suprarenal | NB | Stroma poor. Undif. | 40% | NO | NO |
64 | 2 y | M | Suprarenal | NB | Stroma poor. Undif. | n.a. | n.a. | NO |
73 | 2 y | F | Suprar. retroper | NB | Stroma poor. Undif. | 85% | YES | YES |
77 | 4 y | M | Retroperitoneum | NB | Stroma poor. Undif. | 25% | NO | NO |
85 | 4 y | M | Suprarenal | NB | Stroma poor. Undif. Mild MKI. | 30% | n.a. | NO |
87 | 3 y | M | Hypochondrium | NB | Stroma poor. Undif. High MKI. | 30% | n.a. | YES (10 copies) |
90 | 12 y | n.a. | Brain | NB | n.a. | n.a. | n.a. | n.a. |
91 | 3 y | F | Retroperitoneum | NB | Stroma poor. Undif. | 25% | NO | NO |
95 | 4 m | F | Suprarenal | NB | Stroma poor. Undif. | n.a. | YES | n.a. |
96 | 3 y | F | n.a. | NB | Stroma poor. Undif. | 50% | n.a. | n.a. |
97 | 4 m | F | Suprarenal | NB | Stroma poor. Undif. | 10% | NO | n.a. |
99 | 2 m | F | Thoracic-abdominal | NB | Stroma poor. Undif. High MKI. | 60% | n.a. | n.a. |
102 | 1 y | F | Mediastinum | NB | Stroma poor. Undif. Low MKI. | 15% | YES | NO |