Celecoxib decreases prostaglandin E2concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer

Table 2 Comparison of Median PGE₂ Concentrations in ng/mL in NAF Based on Disease Status¹

	Before (N)	After (N)	Washout (N)	P value
				Before v. After (N)	After v. Washout (N)	Before v. Washout (N)
Population ²
High risk	11.43 (26)	13.22 (22)	14.30 (22)	0.84 (22)	0.91 (21)	0.67 (22)
Cancer	10.70 (12)	8.11 (11)	NA	0.02 (11)
*P value*	0.37	0.11

1: N: sample size; NAF: nipple aspirate fluid; NA: not applicable.
2: Although NAF was collected from both breasts of women with cancer, only NAF from the breast with cancer is included in this Table. In the high risk group, after taking celecoxib NAF collection was unsuccessful in two subjects, and in one the tube broke. In the cancer group, one subject refused NAF collection, and in a second subject the after treatment aspiration was not attempted due to the presence of a needle localization wire.

ISSN: 1471-2407