Table 2 Characteristics, treatment and clinical course of individual patients
RPA class | no. | sex | age (years) | result of neuropathologic reevaluation (% of oligodendroglial component, where applicable) | surgery | total/daily RT dose (Gy) | total/pre-RT adjuv. cycles ACNU/VM26 (reason for termination) | salvage treatment | overall survival (months) |
|---|---|---|---|---|---|---|---|---|---|
III | 1 | m | 34 | GBM with extensive oligodendroglial component (30%) | resection | 55.1/2 × 1.8 | 6 | -- | 40+ |
2 | f | 39 | grade III oligoastrocytoma with transition to GBM | resection | 60.6/2 × 1.8 | 3 (thrombo-cytopenia III°) | 17 × TEM | 41+ | |
IV | 3 | f | 51 | small-cell GBM with extensive oligodendroglial component (75%) | resection | 53.4/2 × 1.8 | 2/1 (leuko-cytopenia II°) | 1 × ACNU/VM26 | 47 |
4 | m | 53 | anaplastic oligodendroglioma with focal transition to GBM | resection | 59.4/1.8 | 5/1 | -- | 82+ | |
5 | f | 73 | GBM with oligodendroglial component (30%) | resection | 59.4/1.8 | 4/2 | reirradiation (6 × 5 Gy), surgery, 1 × TEM | 26 | |
V | 6 | f | 54 | anaplastic oligodendroglioma with transition to GBM | resection | 45/3 | 6 | -- | 41+ |
7 | f | 62 | GBM with minor oligodendroglial component | resection | 54/2 × 1.8 | 2 (progression) | 3 × TEM | 13 | |
8 | f | 54 | GBM with oligodendroglial component (20%) | resection | 45/3 | 1 (thrombo-cytopenia IV°) | -- | 10 | |
VI | 9 | m | 60 | very small tissue sample, anaplastic oligodendroglioma, GBM possible | open biopsy | 54/2 × 1.8 | -- | -- | 7 |
10 | m | 72 | GBM with minor oligodendroglial component (less than 5%) | resection | 45/3 | -- | -- | 10 |