Figure 1

Expression of fascin and Ki67 in normal colonic epithelium, adenomas and adenocarcinomas. a, b: immunohistochemical staining for fascin and Ki67 in normal colonic epithelium. c-g: fascin staining in sporadic adenoma (c, d, f, g) and FAP (e). h-l: fascin and Ki67 staining in a moderately-differentiated adenocarcinoma, (h, k), and a poorly-differentiated adenocarcinoma, (i, l). j: stromal staining of fascin in a colorectal adenocarcinoma. m-p: representative examples of fascin, (m, o), and Ki67 staining, (n, p), in continuous sections from a sporadic adenoma, (m, n), and a moderately-differentiated adenocarcinoma, (o, p). Arrows in o and p indicates examples of areas where fascin and Ki67 are inversely correlated; arrowheads indicate areas where staining is over-lapping.