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Table 2 Association between GSTT1 and GSTM1 and bladder cancer risk among women and men

From: Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2genes and bladder cancer risk in men and women

  NHS HPFS
Genotype Case, n (%) Control, n (%) OR (95% CI)1 OR (95% CI)2 Case, n (%) Control, n (%) OR (95% CI)1 OR (95% CI)2
GSTT1         
Present 50 (76.9) 551 (84.8) 1.00 ref 1.00 ref 106 (83.5) 225 (82.1) 1.00 ref 1.00 ref
Null 14 (21.9) 99 (15.2) 1.63 (0.86, 3.07) 1.57 (0.82, 3.02) 21 (16.5) 49 (17.9) 0.85 (0.48, 1.51) 0.79 (0.44, 1.43)
GSTM1         
Present 33 (51.6) 308 (47.5) 1.00 ref 1.00 ref 49 (38.6) 131 (47.8) 1.00 ref 1.00 ref
Null 31 (47.7) 340 (52.5) 0.84 (0.50, 1.42) 0.78 (0.46, 1.33) 78 (61.4) 143 (52.2) 1.44 (0.93, 2.22) 1.46 (0.93, 2.27)
Combined genotype         
Both present 26 (40.0) 262 (40.4) 1.00 ref 1.00 ref 39 (30.7) 107 (39.1) 1.00 ref 1.00 ref
Either null 31 (48.4) 333 (51.4) 0.92 (0.53, 1.61) 0.91 (0.52, 1.60) 77 (60.6) 142 (51.8) 1.41 (0.89, 2.25) 1.44 (0.89, 2.32)
Both null 7 (10.8) 53 (8.2) 1.40 (0.58, 3.42) 1.19 (0.46, 3.05) 11 (8.7) 25 (9.1) 1.15 (0.52, 2.58) 1.07 (0.47, 2.45)
    P = 0.72 P = 0.95    P = 0.32 P = 0.39
  1. 1 unconditional logistic regression adjusted for age and smoking status
  2. 2 unconditional logistic regression adjusted for age, smoking status, and packyears of smoking