Table 2 Association between GSTT1 and GSTM1 and bladder cancer risk among women and men
From: Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2genes and bladder cancer risk in men and women
| Â | NHS | HPFS | ||||||
|---|---|---|---|---|---|---|---|---|
Genotype | Case, n (%) | Control, n (%) | OR (95% CI)1 | OR (95% CI)2 | Case, n (%) | Control, n (%) | OR (95% CI)1 | OR (95% CI)2 |
GSTT1 | Â | Â | Â | Â | Â | Â | Â | Â |
Present | 50 (76.9) | 551 (84.8) | 1.00 ref | 1.00 ref | 106 (83.5) | 225 (82.1) | 1.00 ref | 1.00 ref |
Null | 14 (21.9) | 99 (15.2) | 1.63 (0.86, 3.07) | 1.57 (0.82, 3.02) | 21 (16.5) | 49 (17.9) | 0.85 (0.48, 1.51) | 0.79 (0.44, 1.43) |
GSTM1 | Â | Â | Â | Â | Â | Â | Â | Â |
Present | 33 (51.6) | 308 (47.5) | 1.00 ref | 1.00 ref | 49 (38.6) | 131 (47.8) | 1.00 ref | 1.00 ref |
Null | 31 (47.7) | 340 (52.5) | 0.84 (0.50, 1.42) | 0.78 (0.46, 1.33) | 78 (61.4) | 143 (52.2) | 1.44 (0.93, 2.22) | 1.46 (0.93, 2.27) |
Combined genotype | Â | Â | Â | Â | Â | Â | Â | Â |
Both present | 26 (40.0) | 262 (40.4) | 1.00 ref | 1.00 ref | 39 (30.7) | 107 (39.1) | 1.00 ref | 1.00 ref |
Either null | 31 (48.4) | 333 (51.4) | 0.92 (0.53, 1.61) | 0.91 (0.52, 1.60) | 77 (60.6) | 142 (51.8) | 1.41 (0.89, 2.25) | 1.44 (0.89, 2.32) |
Both null | 7 (10.8) | 53 (8.2) | 1.40 (0.58, 3.42) | 1.19 (0.46, 3.05) | 11 (8.7) | 25 (9.1) | 1.15 (0.52, 2.58) | 1.07 (0.47, 2.45) |
| Â | Â | Â | P = 0.72 | P = 0.95 | Â | Â | P = 0.32 | P = 0.39 |