Eukaryotic Initiation Factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer

BMC Cancer

Table 3 VEGF and IL-8 in relation to clinicopathological indicators and eIF4E reactivity

Variable	VEGF				p value	IL-8				p value
	(-)	(1+)	(2+)	(3+)		(-)	(1+)	(2+)	(3+)
Total	29	38	34	21		21	40	37	24
Age (median, 56 years)
<56 years	13	21	17	8	0.43	13	18	24	11	0.24
≥56 years	16	17	27	13		8	22	13	13
Tumor size
<3.1 cm	20	20	15	7	0.09	15	20	14	10	0.08
≥3.1 cm	9	18	10	14		6	20	23
Invasive carcinoma grade
Grade I	14	19	8	2	0.003	10	17	8	2	0.022
Grade II	10	12	12	6		6	13	11	9
Grade III	5	7	14	13		5	10	18	13
TNM staging
Stage I	10	14	7	1	0.007	9	13	6	3	0.048
Stage II	9	10	9	3		6	14	10	4
Stage III	7	8	8	4		3	8	9	6
Stage IV	3	6	10	13		3	5	12	11
eIF4E expression
Low reactivity	20	18	17	4	0.007	15	19	20	5	0.007
High reactivity	9	20	17	17		6	21	17	19

ISSN: 1471-2407