Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families

Table 4 Sequence variants detected in Human ATR and residues found in orthologues

SNP	SNP ID*	Amino acid change	Pan troglodytes	Canis familiaris	Mus musculus	Xenapus laevis	Fugu rubribes	Strongylocentrotus purpuratus	Drosophila melanogaste
5**	c.632C>T	Thr211 Met	Thr	Thr	Met	Met	Gly	-	Glu
6	c. 946G>A	Va1316Ile	Val	Val	Val	Val	Val	Ser	Asp
14	c. 2290A>G	Lys764Glu	Lys	Lys	Lys	Lys	Lys	Ser	Glu
16	c. 2875G>A	Val959Met	Met	Met	Ile	Met	Ser	Thr	Phe
34	c. 6394T>G	Tyr2132Asp	Tyr	His	Arg	Gln	Asn	Lys	Ala
39	c. 7274G>A	Arg2425Gln	-	Arg	Gln	Lys	Lys	Glu	Thr

* According to the nomenclature of the Human Genome Variation Society
- No corresponding residue in this species
** T allele is considered as the common allele according to the reference sequence NM_001184

ISSN: 1471-2407