Skip to main content

Table 2 Most Common Chromosomal Copy Number Aberration Among 71 Medulloblastomas.

From: Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8

Chromosome Loss Number (%) p value, log-rank [OS: PFS]
17p loss 36 (50%)* 0.544: 0.816
17p loss and 17q gain (consistent with isochromosome 17q) 23 (32%)* 0.704: 0.874
16q loss 29 (40%) 0.707: 0.889
10q loss 25 (35%) 0.356: 0.252
8p loss 24 (34%) 0.581: 0.423
16p loss 22 (31%) 0.744: 0.736
6q loss 16 (22%) 0.741: 0.345
10p loss 16 (22%) 0.325: 0.386
9q loss 16 (22%) 0.999: 0.703
11p loss 15 (21%) 0.201: 0.212
19p loss 13 (18%) 0.332: 0.282
3q loss 13 (18%) 0.899: 0.439
6p loss 13 (18%) 0.506: 0.095
11q loss 13 (18%) 0.330: 0.375
13q loss 10 (14%) 0.966: 0.611
17q loss 10 (14%) 0.918: 0.889
15q loss 8 (11%) 0.064: 0.596
1p loss 8 (11%) 0.061: 0.167
20q loss 8 (11%) 0.992: 0.780
X loss 8 (11%) 0.958: 0.613
3p loss 7 (10%) 0.476: 0.343
21q loss 7 (10%) 0.397: 0.573
Chromosome Gain Number (%) p value, log-rank [OS: PFS]
17q gain 34 (48%)* 0.794: 0.340
17q gain and 17p loss (consistent with isochromosome 17q) 23 (32%)* 0.704: 0.874
7q gain 21 (30%) 0.927: 0.366
2p gain 16 (22%) 0.394: 0.526
7p gain 16 (22%) 0.394: 0.195
18q gain 11 (15%) 0.896: 0.842
X gain 10 (14%) 0.786: 0.868
2q gain 10 (14%) 0.166: 0.356
17p gain 9 (13%) 0.545: 0.885
5p gain 9 (13%) 0.863: 0.688
18p gain 9 (13%) 0.963: 0.652
1q gain 8 (11%) 0.242: 0.088
9p gain 8 (11%) 0.913: 0.893
19 gain 8 (11%) 0.480: 0.403
8q gain 7 (10%) 0.0141**: 0.0004**
3q gain 7 (10%) 0.212: 0.464
5q gain 7 (10%) 0.657: 0.790
6q gain 7 (10%) 0.551: 0.990
  1. * In 23 cases, 17q gain was detected with concurrent 17p loss, and was consistent with i17q.
  2. ** Statistically significant differences by log-rank testing.