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Table 1 Fold changes in selected genes treated with SB715992 tested by microarray analysis.

From: Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line

    Fold Change
Accession Number Gene Symbol Description 6 h 24 h 48 h
R64130 PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.07 1.74 6.50
AI050866 NODAL nodal homolog (mouse) 1.41 5.28 9.19
NM_001106 ACVR2B activin A receptor, type IIB 5.66 6.50 11.31
NM_005118 TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.23 4.92 11.31
NM_005228 EGFR epidermal growth factor receptor -1.52 -1.15 -2.00
BC001971 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.32 1.23 3.03
BC000125 TGFB1 transforming growth factor, beta 1 (Camurati-Engelmann disease) -1.41 -1.23 -2.00
AA994334 BCL10 B-cell CLL/lymphoma 10 1.74 2.46 12.13
AV654063 KRAS2 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog 18.38 13.00 19.70
NM_004464 FGF5 fibroblast growth factor 5 -1.32 -7.46 -6.06
AK027071 TSC22 transforming growth factor beta 1 induced transcript 4 NC 2.83 5.28
BG326045 BHLHB2 basic helix-loop-helix domain containing, class B, 2 -1.15 2.64 9.19
U73844 ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific) -1.07 2.64 6.96
S75264 WT1 Wilms tumor 1 -1.15 -1.41 -4.59
AW514564 CHD2 chromodomain helicase DNA binding protein 2 -1.07 3.48 14.93
AF180474 CNOT3 CCR4-NOT transcription complex, subunit 3 -1.52 -2.14 -4.29
N95363 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -2.00 1.23 6.06
AL039795 TARDBP TAR DNA binding protein 1.52 4.29 10.56
AK022513 DUSP10 dual specificity phosphatase 10 -1.32 3.73 8.57
AA994004 CDK11 cyclin-dependent kinase (CDC2-like) 11 8.57 8.00 128.00
L78790 ITGB2 integrin, beta 2 (antigen CD18 (p95) -1.23 -1.32 -10.56
NM_003954 MAP3K14 mitogen-activated protein kinase kinase kinase 14 -1.15 -1.41 -2.64
NM_030662 MAP2K2 mitogen-activated protein kinase kinase 2 -1.32 -1.32 -2.00
AW025150 MAP3K12 mitogen-activated protein kinase kinase kinase 12 1.32 -1.15 -2.00
AW450910 SYK spleen tyrosine kinase -1.52 -1.52 -14.93
M57765 IL11 interleukin 11 1.07 -2.00 -4.59
AW444761 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.07 6.06 9.19
NM_002031 FRK fyn-related kinase 4.29 6.96 25.99