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Table 1 Fold changes in selected genes treated with SB715992 tested by microarray analysis.

From: Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line

   

Fold Change

Accession Number

Gene Symbol

Description

6 h

24 h

48 h

R64130

PPBP

pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)

1.07

1.74

6.50

AI050866

NODAL

nodal homolog (mouse)

1.41

5.28

9.19

NM_001106

ACVR2B

activin A receptor, type IIB

5.66

6.50

11.31

NM_005118

TNFSF15

tumor necrosis factor (ligand) superfamily, member 15

1.23

4.92

11.31

NM_005228

EGFR

epidermal growth factor receptor

-1.52

-1.15

-2.00

BC001971

CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

1.32

1.23

3.03

BC000125

TGFB1

transforming growth factor, beta 1 (Camurati-Engelmann disease)

-1.41

-1.23

-2.00

AA994334

BCL10

B-cell CLL/lymphoma 10

1.74

2.46

12.13

AV654063

KRAS2

v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog

18.38

13.00

19.70

NM_004464

FGF5

fibroblast growth factor 5

-1.32

-7.46

-6.06

AK027071

TSC22

transforming growth factor beta 1 induced transcript 4

NC

2.83

5.28

BG326045

BHLHB2

basic helix-loop-helix domain containing, class B, 2

-1.15

2.64

9.19

U73844

ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific)

-1.07

2.64

6.96

S75264

WT1

Wilms tumor 1

-1.15

-1.41

-4.59

AW514564

CHD2

chromodomain helicase DNA binding protein 2

-1.07

3.48

14.93

AF180474

CNOT3

CCR4-NOT transcription complex, subunit 3

-1.52

-2.14

-4.29

N95363

CDKN1C

cyclin-dependent kinase inhibitor 1C (p57, Kip2)

-2.00

1.23

6.06

AL039795

TARDBP

TAR DNA binding protein

1.52

4.29

10.56

AK022513

DUSP10

dual specificity phosphatase 10

-1.32

3.73

8.57

AA994004

CDK11

cyclin-dependent kinase (CDC2-like) 11

8.57

8.00

128.00

L78790

ITGB2

integrin, beta 2 (antigen CD18 (p95)

-1.23

-1.32

-10.56

NM_003954

MAP3K14

mitogen-activated protein kinase kinase kinase 14

-1.15

-1.41

-2.64

NM_030662

MAP2K2

mitogen-activated protein kinase kinase 2

-1.32

-1.32

-2.00

AW025150

MAP3K12

mitogen-activated protein kinase kinase kinase 12

1.32

-1.15

-2.00

AW450910

SYK

spleen tyrosine kinase

-1.52

-1.52

-14.93

M57765

IL11

interleukin 11

1.07

-2.00

-4.59

AW444761

CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

1.07

6.06

9.19

NM_002031

FRK

fyn-related kinase

4.29

6.96

25.99