HOMUR cells that are resistant to DCA-induced apoptosis exhibit resistance to other anti-cancer agents. Parental HCT116 cells and HOMUR 7, 11, and 17 cells were plated at a density of 100,000 cells per 35 mm plate and incubated at 37°C for 48 hours. Subsequently etoposide (panel A) was added to a final concentration of 50 μM, cisplatin (panel B) added to a final concentration of 50 μM, or adriamycin (panel C) added to a final concentration of 1 μM to the plates. The cells were incubated with the drugs for 36 hours and then the number of apoptotic cells quantitated as described in Methods. The bars represent average values of three replicates. Error bars depict standard deviation. Astrisks denote a significant difference (p < 0.05) when compared with parental HCT116 cells.