Figure 3

Selected HOMUR cells show resistance to DCA-induced and hyoDCA-induced apoptosis. HCT116, HOMUR 7, HOMUR 11, or HOMUR 17 cells were plated onto 60 mm plates and allowed to attach for 48 hours. Plates were then incubated either with (A) 500 micromolar DCA for 24 hours or (B) with 500 micromolar hyoDCA for 48 hours. Apoptosis in each culture was quantitated as described in Methods. Bars represent the average of triplicate results. Error bars represent standard deviation. Astrisks indicate a significant difference (p < 0.05) when compared with parental HCT116 cells.