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Table 1 Interaction between GPX1 Pro198Leu and MnSOD Val16Ala polymorphisms and breast cancer risk in the Nurses' Health Study

From: Gene × Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study

Genotype

Cases (%)*

Controls (%)*

OR (95% CI)**

Pro198 carrier and Val16 carrier

771 (67.0)

997 (67.4)

1.00 (Ref.)

Leu198Leu and Val16 carrier

90 (7.8)

124 (8.4)

0.94 (0.69 – 1.27)

Pro198 carrier and Ala16Ala

255 (22.2)

331 (22.4)

1.01 (0.83 – 1.23)

Leu198Leu and Ala16Ala

35 (3.0)

28 (1.9)

1.87 (1.09 – 3.19)

  1. * Samples failing genotyping for both assays were removed from the analyses
  2. ** Unconditional logistic regression, controlled for fasting status, date and time of blood draw, age at blood draw (5 year categories), menopausal status, recent post-menopausal hormone use at blood draw, age at menopause, age at menarche, body mass index at age 18, weight gain since age 18, age at fist birth/parity, history of benign breast disease, and family history of breast cancer. Interaction p-value = 0.03.
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