Skip to main content
Figure 2 | BMC Cancer

Figure 2

From: Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio

Figure 2

Sensitisation by HDACIs to TRAIL requires an intact TRAIL receptor pathway. A SH-EP and SH-EP-FADD-DN cells were treated 48 h without TRAIL or with TRAIL (50 ng/ml) and M2 (250 ng/ml) in the presence or absence of NaB (1 mM), SAHA (2.5 μM) or TSA (0.5 μM).B No induction in cell surface expression of TRAIL and TRAIL receptors induced by HDACIs in NB cells. SH-EP cells treated for 24 h with NaB (1 mM), SAHA (2.5 μM) or TSA (0.5 μM) were incubated with antibody against TRAIL-R1, TRAIL-R2 and TRAIL (thick line) or without primary antibody (thin line) and then with a FITC labelled secondary antibody.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us