Cell Clone | Number of Independent Experiments | Expression of Bcl-2 or Bcl-XL proteins (ng/μg total protein) no drug | Expression of Bcl-2 or Bcl-XL proteins (ng/μg total protein) at the EC50 dose of doxorubicin | EC 50 doxorubicin (μM) Inhibition of PARP degradation. |
---|---|---|---|---|
Neo | 5 | n.d. | n.d. | 1.9 ± 0 |
Bcl-2 (#2) | 6 | 4.5 ± 1.0 | 2.5 ± 0.1 | 22.8 ± 3.3 |
Bcl-2 (#5) | 7 | 3.6 ± 0.7 | 1.6 ± 0.1 | 30.6 ± 1.0 |
Bcl2-acta (#24) | 7 | 1.2 ± 0.3 | 0.2 ± 0.02 | 13.2 ± 1.7 |
Bcl2-cb5 (#18) | 5 | 1.5 ± 0.4 | 1.3 ± 0.02 | 2.3 ± 0.1 |
Bcl-XL (#42) | 6 | 0.8 ± 0.2 | 0.7 ± 0.05 | 85.4 ± 0.6 |
BclX-Δt (#1) | 5 | 0.6 ± 0.1 | 0.5 ± 0.01 | 8.7 ± 1.7 |
BclX-acta (#6) | 4 | 0.3 ± 0.1 | 0.2 ± 0.02 | 97.8 ± 1.5 |
BclX-cb5 (#24) | 5 | 0.6 ± 0.1 | 0.6 ± 0.1 | 32.3 ± 1.8 |