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Table 4 Association of CpG island hypermethylation and clinico-pathological parameters in ovarian cancer.

From: Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data

 

All Subjects

p14

BRCA1

PTEN

p16

Any loci

  

+

-

+

-

+

-

+

-

+

-

Cases

49

12

37

8

41

4

45

9

40

25

24

Mean age (yrs)

48.8

47.6

49.2

44.0

49.8

65.1

47.4

52.6

48.0

47.8

49.9

P value (T-test)

  

0.7

 

0.239

 

0.006

 

0.321

 

0.559

Stage

           

   I-II

24

9

15

2

22

2

22

4

20

12

12

   III-IV

25

3

22

6

19

2

23

5

20

13

12

P value (χ2 test)

  

0.038

 

0.138

 

0.966

 

0.763

 

0.889

Gradea

           

   G1–2

22

9

13

1

21

4

18

6

16

13

9

   G3

25

3

22

7

18

0

25

3

22

12

13

   P value (χ2 test)

  

0.023

 

0.033

 

0.026

 

0.184

 

0.447

Histological type

49

          

   Serous

17

2

15

6

11

1

16

3

14

11

6

   Mucinous

10

3

7

1

9

3

7

6

4

7

3

   Endometrioid

10

3

7

1

9

0

10

0

10

3

7

   Clear-cell

6

3

3

0

6

0

6

0

6

3

3

   Others

6

1

5

0

6

0

6

0

6

1

5

P value (χ2 test]

  

0.08b

 

0.015c

 

0.023d

 

<0.001e

 

0.015e

  1. aWho grading was not available for 2 cases.
  2. bComparison was made between mucinous/endometrioid/clear-cell and the other types.
  3. cComparison was made between serous and the other types.
  4. dComparison was made between mucinous and the other types.
  5. eComparison was made between serous/mucinous and the other types.