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Table 4 Association of CpG island hypermethylation and clinico-pathological parameters in ovarian cancer.

From: Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data

  All Subjects p14 BRCA1 PTEN p16 Any loci
   + - + - + - + - + -
Cases 49 12 37 8 41 4 45 9 40 25 24
Mean age (yrs) 48.8 47.6 49.2 44.0 49.8 65.1 47.4 52.6 48.0 47.8 49.9
P value (T-test)    0.7   0.239   0.006   0.321   0.559
Stage            
   I-II 24 9 15 2 22 2 22 4 20 12 12
   III-IV 25 3 22 6 19 2 23 5 20 13 12
P value (χ2 test)    0.038   0.138   0.966   0.763   0.889
Gradea            
   G1–2 22 9 13 1 21 4 18 6 16 13 9
   G3 25 3 22 7 18 0 25 3 22 12 13
   P value (χ2 test)    0.023   0.033   0.026   0.184   0.447
Histological type 49           
   Serous 17 2 15 6 11 1 16 3 14 11 6
   Mucinous 10 3 7 1 9 3 7 6 4 7 3
   Endometrioid 10 3 7 1 9 0 10 0 10 3 7
   Clear-cell 6 3 3 0 6 0 6 0 6 3 3
   Others 6 1 5 0 6 0 6 0 6 1 5
P value (χ2 test]    0.08b   0.015c   0.023d   <0.001e   0.015e
  1. aWho grading was not available for 2 cases.
  2. bComparison was made between mucinous/endometrioid/clear-cell and the other types.
  3. cComparison was made between serous and the other types.
  4. dComparison was made between mucinous and the other types.
  5. eComparison was made between serous/mucinous and the other types.