Breast cancer screening in women at increased risk according to different family histories: an update of the Modena Study Group experience

Table 4 Characteristics of patients with interval cancer

Age (years)	Risk group	Detection method	Time from the last negative exam (months)	Type of tumor	Tumor size (cm)	Stage	Grading	Hormonal receptors ER/PgR (%)	Ki67 (%)
49	Intermediate	CBE	10	Inflammatory	4*	IV	3	0/0	nd
64	Slightly increased	CBE	1	DCI	0.2°	II	3	90/90	10
51	High	CBE	9§	LCI	1.5	I	3	80/80	20
45	Intermediate	CBE	14	DCIS∞	0.6	is	1	0/0	nd
32•	Slightly increased	CBE+US	10	LCI	2	III	3	80/30	20
47	BRCA+	CBE+US	3^®	DCI	1.2	I	3	0/0	60
45	High	CBE+US^©	5	DCI	0.7	I	3	70/80	60
46	Intermediate	CBE+US+Mx^©	10	DCI	1.6	II	3	0/0	10

* The tumor size was determined at the time of mastectomy, after 8 cycles of preoperative chemotherapy
° Patient was diagnosed with axillary node involvement in the absence of radiological mammary signs; at the left upper outer quadrantectomy, a 0.2 cm focus of DCI was evidenced
§Nine months prior to diagnosis, a fine needle aspiration of microcalcification clusters was negative for atypical cells
∞ Eleven months prior to diagnosis, a nipple discharge cytology was negative for atypical cells. Then she spontaneously contacted a surgeon who performed a subareolar biopsy that showed multiple foci of DCIS. She subsequently underwent mastectomy.
• No mammography was done before the diagnosis in consideration of the slightly increased risk and the young age of the patient
^®Three months prior to diagnosis, an MRI showed a 9 mm lump in the lower left outer quadrant, with a fast wash in and wash out which was diagnosed as an intramammary lymph node.
Note.nd -not determined ;ER – estrogen receptor; PgR – progesterone receptor; DCI -ductal carcinoma infiltrating ; LCI – lobular carcinoma infiltrating; DCIS – ductal carcinoma in situ

ISSN: 1471-2407