Breast cancer screening in women at increased risk according to different family histories: an update of the Modena Study Group experience

Table 1 Modena model

High risk			Pedigree classification
I) at least 3 relatives diagnosed with BC (or OC) in 2 different generations	II) one BC/OC case is a first-degree relative of the other 2 (of the other 1 if the first criterion is not fulfilled)°	III) at least one case has been diagnosed at the age ≤ 40 or with bilateral BC
•	•	•	H ereditary	HBC/*HBOC
•	•		S uspected H ereditary	SHBC/SHBOC
•		•	S uspected H ereditary	SHBC/SHBOC
BC diagnosed at age ≤ 35, regardless of family history			E arly O nset	EOBC
BC and OC in the same woman, regardless of family history			B reast O varian C ancer	BOC
Intermediate risk
•			F amilial	FBC/FBOC
	•	•	S trongly S uspected F amilial	SFBC+ SFBOC+
Male BC, regardless of family history			M ale B reast C ancer	MBC
Slightly increased risk
	•		S uspected F amilial	SFBC/SFBOC
		•	S uspected F amilial	SFBC/SFBOC
BC/OC without any of the described criteria			S poradic B reast C ancer	SpBC/SpOC

° male relatives excluded when calculating the degree of relationship
* If at least two of the malignancies are OC, the pedigree must be classified as HBOC even if the third criterion is not fulfilled.
**At least two cancer cases are required
HBC – hereditary breast cancer; HBOC -hereditary breast/ovarian cancer; SHBC-suspected hereditary breast cancer; SHBOC-suspected hereditary breast/ovarian cancer; EOBC-early onset breast cancer; BOC-breast ovarian cancer; FBC-familial breast cancer; FBOC-familial breast/ovarian cancer; SFBC+- strongly suspected familial breast cancer; SFBOC+- strongly suspected familial breast/ovarian cancer; MBC-male breast cancer; SFBC- weakly suspected familial breast cancer; SFBOC- weakly suspected familial breast/ovarian cancer; SpBC- sporadic breast cancer; SpOC-sporadic ovarian cancer

ISSN: 1471-2407