Table 2 Multiple cancer and bilateral breast cancer among unselected and familial breast cancer patients, by ATMex39 D1853N and ATMivs38(-8)T>C genotype
From: ATM variants and cancer risk in breast cancer patients from Southern Finland
ATMex39 D1853N | total | DD | DN | NN | OR (95% CI)* | p | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Unselected breast cancer patients | 803 | 485 | 285 | 33 | ||||||
Bilateral | 52 | 6.5% | 37 | 7.6% | 14 | 4.9% | 1 | 3.0% | 0.60 (0.32–1.11) | 0.11 |
Unilateral | 751 | 93.5% | 448 | 92.4% | 271 | 95.1% | 32 | 97.0% | ||
Multiple cancer | 83 | 10.3% | 51 | 10.5% | 31 | 10.9% | 1 | 3.0% | 0.95 (0.60–1.52) | 0.91 |
Breast cancer only | 720 | 89.7% | 434 | 89.5% | 254 | 89.1% | 32 | 97.0% | ||
Familial breast cancer patients | 778 | 469 | 276 | 33 | ||||||
Bilateral | 86 | 11.1% | 53 | 11.3% | 30 | 10.9% | 3 | 9.1% | 0.94 (0.59–1.49) | 0.82 |
Unilateral | 692 | 88.9% | 416 | 88.7% | 246 | 89.1% | 30 | 90.9% | ||
Multiple cancer | 89 | 11.4% | 57 | 12.2% | 29 | 10.5% | 3 | 9.1% | 0.84 (0.53–1.32) | 0.49 |
Breast cancer only | 689 | 88.6% | 412 | 87.8% | 247 | 89.5% | 30 | 90.9% | ||
*DN+NN vs. DD | ||||||||||
ATMivs38 (-8)T>C | total | TT | TC | OR (95% CI) | p | |||||
Unselected breast cancer patients | 818 | 769 | 49 | |||||||
Bilateral | 49 | 6.0% | 45 | 5.9% | 4 | 8.2% | 1.43 (0.49–4.15) | 0.53 | ||
Unilateral | 769 | 94.0% | 724 | 94.1% | 45 | 91.8% | ||||
Multiple cancer | 80 | 9.8% | 70 | 9.1% | 10 | 20.4% | 2.56 (1.23–5.35) | 0.02 | ||
Breast cancer only | 738 | 90.2% | 699 | 90.1% | 39 | 79.6% | ||||
Familial breast cancer patients | 774 | 717 | 57 | |||||||
Bilateral | 84 | 10.9% | 78 | 10.9% | 6 | 10.5% | 0.96 (0.40–2.32) | 1.0 | ||
Unilateral | 690 | 89.1% | 639 | 89.1% | 51 | 89.5% | ||||
Multiple cancer | 92 | 11.9% | 85 | 11.9% | 7 | 12.3% | 1.04 (0.46–2.37) | 0.83 | ||
Breast cancer only | 682 | 88.1% | 632 | 88.1% | 50 | 87.7% | ||||