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Table 2 Mean normalized ERCC1, OGG1 and RAI mRNA levels in normal colonic mucosa and lesions.

From: Increased mRNA expression levels of ERCC1, OGG1 and RAIin colorectal adenomas and carcinomas

  ERCC1    OGG1    RAI   
  Mean level × 1000a    Mean level × 1000a    Mean level × 1000a   
Type of tissue Normal Lesions Pb 95% CI Normal Lesions Pb 95% CI Normal Lesions Pb 95% CI
All cases combined 0.55 1.8 0.005 (0.4 ;2.2) 0.33 1.83 3*10 -5 (0.9 ; 2.1) 0.26 2.0 0.0005 (0.8 ; 2.7)
Adenomasc             
   Mild/moderate 0.76 2.2 0.151 (-0.9 ; 3.5) 0.44 2.13 0.069 (-0.2 ; 3.6) 0.31 3.1 0.135 (-1.6 ; 6.6)
   Severe 0.39 1.5 0.027 (0.15 ; 2.1) 0.35 1.68 0.004 (0.5 ; 2.2) 0.28 1.85 0.0014 (0.4 ; 1.5)
CRC 0.16 1.5 0.109 (-0.4 ; 3.1) 0.24 1.83 0.034 (0.2 ; 3.0) 0.18 1.46 0.09 (-0.3 ; 2.8)
  1. a) Since ERCC1, OGG1 and RAI expression is expressed as a ratio, normalized, to 18S rRNA expression, it is unit-less.
  2. b) Comparison of the expression levels in lesions and normal colonic mucosa from the same persons.
  3. c) The adenomas are divided in groups according to mild/moderate dysplasia or severe dysplasia.