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Table 3 Cox Regression of Risk of Death in Association with MCM2, Ki-67, and Gelsolin in 128 Patients with NSCLC, RPCI, 1995–1999

From: Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer

Variables

Crude RR (95%CI)

P value

Adjusted RR (95%CI)*

P value

MCM2†

    

   Low (n = 49)

1.00

 

1.00

 

   High (n = 79)

1.51 (0.94–2.41)

0.09

1.36 (0.84–2.20)

0.22

Ki-67 ‡

    

   Low (n = 28)

1.00

 

1.00

 

   High (n = 100)

0.70 (0.27–1.86)

0.47

0.59 (0.22–1.61)

0.30

Gelsolin †

    

   Low (n = 86)

1.00

 

1.00

 

   High (n = 42)

1.89 (1.20–2.98)

0.006

1.89 (1.17–3.05)

0.01

Gelsolin and MCM2 †

    

   Both low (n = 37)

1.00

 

1.00

 

   GSN low, MCM2 high (n = 49)

1.34 (0.74–2.42)

0.33

1.34 (0.73–2.45)

0.34

   GSN high, MCM2 low (n = 12)

1.62 (0.70–3.73)

0.26

2.08 (0.87–4.98)

0.10

   GSN high, MCM2 high (n = 30)

2.59 (1.39–4.80)

0.003

2.32 (1.21–4.45)

0.01

  1. * Adjusted for age, stage, adjuvant chemotherapy, family history of lung cancer, and smoking history.
  2. † Results from Cox Proportional Hazards Regression.
  3. ‡ Results from time-dependent Cox Regression.