Figure 3

The mRNA expression data for A. eight ovarian cancer cell lines, and B. 50 ovarian carcinomas. The ovarian cancer cell lines and the ovarian carcinomas are ordered according to their cisplatin and platinum-based chemotherapy response. The MMR status deducted from the mRNA expression levels is given for the carcinomas (1: active, 0: inactive). The mRNA expression is shown in the heatmap (green color: low expression (25^th percentile calculated per gene), black: median expression, red color: high expression (75^th percentile calculated per gene), gray: no value). Depicted next to the heatmap is: the MLH1 promoter methylation status (black: complete or high level, gray: low level, white: no methylation, X: unknown), the microsatellite stability (black: instable, white: stable, X: unknown), the cisplatin response (Figure 3A; IC50 in nM) or platinum-based chemotherapy response (Figure 3B; black: non-responders, white: responders, X: unknown) and the histology (PD: poorly differentiated, SE: serous, CC: clear cell, MU: mucinous, EN: endometrioid, MM: mixed mullerian). Cell lines and carcinomas are ordered according to their cisplatin response or platinum-based chemotherapy response respectively.